Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia
Pseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the <i>Yersinia pseudotuberculosis</i> (<i>Y. pseudotuberculosis&...
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MDPI AG
2020-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/6/436 |
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| author | Larisa M. Somova Fedor F. Antonenko Nelly F. Timchenko Irina N. Lyapun |
| author_facet | Larisa M. Somova Fedor F. Antonenko Nelly F. Timchenko Irina N. Lyapun |
| author_sort | Larisa M. Somova |
| collection | DOAJ |
| description | Pseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the <i>Yersinia pseudotuberculosis</i> (<i>Y. pseudotuberculosis</i>) infection often causes outbreaks of the disease with serious systemic inflammatory symptoms, and this variant of the disease has been known since 1959 as Far Eastern Scarlet-like Fever (FESLF). Russian researchers have proven that the FESLF pathogen is associated with a concrete clonal line of <i>Y. pseudotuberculosis,</i> characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and <i>yadA</i> gene allele (1st allele). This review summarized the most important achievements in the study of FESLF since its discovery in the Far East. It has been established that the FESLF causative agent is characterized by a unique phenomenon of psychrophilicity, which consists of its ability to reproduce in the environment with its biologically low and variable temperature (4–12 °C), at which the pathogen multiplies and accumulates while maintaining or increasing its virulence, which ensures the emergence and development of the epidemic process. The key genetic and biochemical mechanisms of <i>Y. pseudotuberculosis</i> adaptation to changing environmental conditions were characterized, and the morphological manifestations of the adaptive variability of these bacteria in different conditions of their habitat were revealed. The main features of the pathogenesis and morphogenesis of FESLF, including those associated with the <i>Y. pseudotuberculosis</i> toxigenicity, were presented. The pathogenetic value of the plasmid PVM82, found only in the FESLF pathogen, was shown. |
| first_indexed | 2024-03-10T19:26:19Z |
| format | Article |
| id | doaj.art-f4d32213ff7f416a9dd40bf59ef5c4dc |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T19:26:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-f4d32213ff7f416a9dd40bf59ef5c4dc2023-11-20T02:36:05ZengMDPI AGPathogens2076-08172020-06-019643610.3390/pathogens9060436Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in RussiaLarisa M. Somova0Fedor F. Antonenko1Nelly F. Timchenko2Irina N. Lyapun3Somov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, RussiaRussian Scientific Center for Roentgen-Radiology, Ministry of Health, 117997 Moscow, RussiaSomov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, RussiaSomov Research Institute of Epidemiology and Microbiology, Ministry of Science and Higher Education, 690087 Vladivostok, RussiaPseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the <i>Yersinia pseudotuberculosis</i> (<i>Y. pseudotuberculosis</i>) infection often causes outbreaks of the disease with serious systemic inflammatory symptoms, and this variant of the disease has been known since 1959 as Far Eastern Scarlet-like Fever (FESLF). Russian researchers have proven that the FESLF pathogen is associated with a concrete clonal line of <i>Y. pseudotuberculosis,</i> characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and <i>yadA</i> gene allele (1st allele). This review summarized the most important achievements in the study of FESLF since its discovery in the Far East. It has been established that the FESLF causative agent is characterized by a unique phenomenon of psychrophilicity, which consists of its ability to reproduce in the environment with its biologically low and variable temperature (4–12 °C), at which the pathogen multiplies and accumulates while maintaining or increasing its virulence, which ensures the emergence and development of the epidemic process. The key genetic and biochemical mechanisms of <i>Y. pseudotuberculosis</i> adaptation to changing environmental conditions were characterized, and the morphological manifestations of the adaptive variability of these bacteria in different conditions of their habitat were revealed. The main features of the pathogenesis and morphogenesis of FESLF, including those associated with the <i>Y. pseudotuberculosis</i> toxigenicity, were presented. The pathogenetic value of the plasmid PVM82, found only in the FESLF pathogen, was shown.https://www.mdpi.com/2076-0817/9/6/436<i>Yersinia pseudotuberculosis</i>infectionepidemic |
| spellingShingle | Larisa M. Somova Fedor F. Antonenko Nelly F. Timchenko Irina N. Lyapun Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia Pathogens <i>Yersinia pseudotuberculosis</i> infection epidemic |
| title | Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia |
| title_full | Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia |
| title_fullStr | Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia |
| title_full_unstemmed | Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia |
| title_short | Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of <i>Yersinia pseudotuberculosis</i> Infection in Russia |
| title_sort | far eastern scarlet like fever is a special clinical and epidemic manifestation of i yersinia pseudotuberculosis i infection in russia |
| topic | <i>Yersinia pseudotuberculosis</i> infection epidemic |
| url | https://www.mdpi.com/2076-0817/9/6/436 |
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