Release of free fatty acids from adipose tissue obtained from newborn infants

The role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A ma...

Full description

Bibliographic Details
Main Authors: Milan Novák, Václav Melichar, Petr Hahn, Otakar Koldovský
Format: Article
Language:English
Published: Elsevier 1965-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520396449
_version_ 1818743101564387328
author Milan Novák
Václav Melichar
Petr Hahn
Otakar Koldovský
author_facet Milan Novák
Václav Melichar
Petr Hahn
Otakar Koldovský
author_sort Milan Novák
collection DOAJ
description The role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A maximum level was reached within 24 hr after birth, after which there was a gradual fall. In serum the FFA level at the end of 12 months was still higher than that in adults, while the FFA level in adipose tissue was lower at 3 months than in adults.Incubation of small pieces of adipose tissue in Krebs-Ringer phosphate buffer containing 4%, albumin led to release of FFA into the medium. This release could be suppressed by the addition of glucose (200 mg/100 ml) for tissue from all age groups except the youngest (0–15 hr after birth).
first_indexed 2024-12-18T02:23:04Z
format Article
id doaj.art-f4d363fdc2ba4291852f7fb1653973c5
institution Directory Open Access Journal
issn 0022-2275
language English
last_indexed 2024-12-18T02:23:04Z
publishDate 1965-01-01
publisher Elsevier
record_format Article
series Journal of Lipid Research
spelling doaj.art-f4d363fdc2ba4291852f7fb1653973c52022-12-21T21:24:06ZengElsevierJournal of Lipid Research0022-22751965-01-01619195Release of free fatty acids from adipose tissue obtained from newborn infantsMilan Novák0Václav Melichar1Petr Hahn2Otakar Koldovský3Institute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaThe role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A maximum level was reached within 24 hr after birth, after which there was a gradual fall. In serum the FFA level at the end of 12 months was still higher than that in adults, while the FFA level in adipose tissue was lower at 3 months than in adults.Incubation of small pieces of adipose tissue in Krebs-Ringer phosphate buffer containing 4%, albumin led to release of FFA into the medium. This release could be suppressed by the addition of glucose (200 mg/100 ml) for tissue from all age groups except the youngest (0–15 hr after birth).http://www.sciencedirect.com/science/article/pii/S0022227520396449free fatty acidsadipose tissueinfantsincubationneedle aspirationmetabolism
spellingShingle Milan Novák
Václav Melichar
Petr Hahn
Otakar Koldovský
Release of free fatty acids from adipose tissue obtained from newborn infants
Journal of Lipid Research
free fatty acids
adipose tissue
infants
incubation
needle aspiration
metabolism
title Release of free fatty acids from adipose tissue obtained from newborn infants
title_full Release of free fatty acids from adipose tissue obtained from newborn infants
title_fullStr Release of free fatty acids from adipose tissue obtained from newborn infants
title_full_unstemmed Release of free fatty acids from adipose tissue obtained from newborn infants
title_short Release of free fatty acids from adipose tissue obtained from newborn infants
title_sort release of free fatty acids from adipose tissue obtained from newborn infants
topic free fatty acids
adipose tissue
infants
incubation
needle aspiration
metabolism
url http://www.sciencedirect.com/science/article/pii/S0022227520396449
work_keys_str_mv AT milannovak releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants
AT vaclavmelichar releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants
AT petrhahn releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants
AT otakarkoldovsky releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants