Release of free fatty acids from adipose tissue obtained from newborn infants
The role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A ma...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
1965-01-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520396449 |
_version_ | 1818743101564387328 |
---|---|
author | Milan Novák Václav Melichar Petr Hahn Otakar Koldovský |
author_facet | Milan Novák Václav Melichar Petr Hahn Otakar Koldovský |
author_sort | Milan Novák |
collection | DOAJ |
description | The role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A maximum level was reached within 24 hr after birth, after which there was a gradual fall. In serum the FFA level at the end of 12 months was still higher than that in adults, while the FFA level in adipose tissue was lower at 3 months than in adults.Incubation of small pieces of adipose tissue in Krebs-Ringer phosphate buffer containing 4%, albumin led to release of FFA into the medium. This release could be suppressed by the addition of glucose (200 mg/100 ml) for tissue from all age groups except the youngest (0–15 hr after birth). |
first_indexed | 2024-12-18T02:23:04Z |
format | Article |
id | doaj.art-f4d363fdc2ba4291852f7fb1653973c5 |
institution | Directory Open Access Journal |
issn | 0022-2275 |
language | English |
last_indexed | 2024-12-18T02:23:04Z |
publishDate | 1965-01-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Lipid Research |
spelling | doaj.art-f4d363fdc2ba4291852f7fb1653973c52022-12-21T21:24:06ZengElsevierJournal of Lipid Research0022-22751965-01-01619195Release of free fatty acids from adipose tissue obtained from newborn infantsMilan Novák0Václav Melichar1Petr Hahn2Otakar Koldovský3Institute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaInstitute for the Care of Mother and Child and Institute of Physiology, Czechoslovak Academy of Sciences, Prague, CzechoslovakiaThe role played by mobilization of free fatty acids (FFA) from adipose tissue in producing the typically high serum FFA levels of human infants has been studied. FFA concentrations in the serum and subcutaneous adipose tissue from the gluteal region were determined during postnatal development. A maximum level was reached within 24 hr after birth, after which there was a gradual fall. In serum the FFA level at the end of 12 months was still higher than that in adults, while the FFA level in adipose tissue was lower at 3 months than in adults.Incubation of small pieces of adipose tissue in Krebs-Ringer phosphate buffer containing 4%, albumin led to release of FFA into the medium. This release could be suppressed by the addition of glucose (200 mg/100 ml) for tissue from all age groups except the youngest (0–15 hr after birth).http://www.sciencedirect.com/science/article/pii/S0022227520396449free fatty acidsadipose tissueinfantsincubationneedle aspirationmetabolism |
spellingShingle | Milan Novák Václav Melichar Petr Hahn Otakar Koldovský Release of free fatty acids from adipose tissue obtained from newborn infants Journal of Lipid Research free fatty acids adipose tissue infants incubation needle aspiration metabolism |
title | Release of free fatty acids from adipose tissue obtained from newborn infants |
title_full | Release of free fatty acids from adipose tissue obtained from newborn infants |
title_fullStr | Release of free fatty acids from adipose tissue obtained from newborn infants |
title_full_unstemmed | Release of free fatty acids from adipose tissue obtained from newborn infants |
title_short | Release of free fatty acids from adipose tissue obtained from newborn infants |
title_sort | release of free fatty acids from adipose tissue obtained from newborn infants |
topic | free fatty acids adipose tissue infants incubation needle aspiration metabolism |
url | http://www.sciencedirect.com/science/article/pii/S0022227520396449 |
work_keys_str_mv | AT milannovak releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants AT vaclavmelichar releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants AT petrhahn releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants AT otakarkoldovsky releaseoffreefattyacidsfromadiposetissueobtainedfromnewborninfants |