Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study)
Cross-sectional and longitudinal studies exploring clinical, functional and biological correlates of Major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2016.00150/full |
| _version_ | 1818309565748346880 |
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| author | Bernhard Theodor Baune Tracy Air |
| author_facet | Bernhard Theodor Baune Tracy Air |
| author_sort | Bernhard Theodor Baune |
| collection | DOAJ |
| description | Cross-sectional and longitudinal studies exploring clinical, functional and biological correlates of Major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including a) cognitive performance, b) emotion processing and c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological genomic correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015 including patients with a primary diagnosis of a major depressive episode of MDD or Bipolar Disorder according to DSM—IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, social cognition), cognitive function screening instrument, plus functional scales to assess general, work place and psychosocial function, depression symptom scales and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focussing on cognitive dimensions of depression and its functional and biological genomic correlates. The CoFaMS team welcomes collaborations with both national and international researchers. |
| first_indexed | 2024-12-13T07:32:12Z |
| format | Article |
| id | doaj.art-f4d3d47f2b364b77bc36618164a68415 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T07:32:12Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-f4d3d47f2b364b77bc36618164a684152022-12-21T23:55:11ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402016-08-01710.3389/fpsyt.2016.00150208980Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study)Bernhard Theodor Baune0Tracy Air1University of AdelaideUniversity of AdelaideCross-sectional and longitudinal studies exploring clinical, functional and biological correlates of Major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including a) cognitive performance, b) emotion processing and c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological genomic correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015 including patients with a primary diagnosis of a major depressive episode of MDD or Bipolar Disorder according to DSM—IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, social cognition), cognitive function screening instrument, plus functional scales to assess general, work place and psychosocial function, depression symptom scales and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focussing on cognitive dimensions of depression and its functional and biological genomic correlates. The CoFaMS team welcomes collaborations with both national and international researchers.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2016.00150/fullDepressionsocial cognitionCognitive FunctionGenomic biomarkersCognitive DimensionsBiological correlates |
| spellingShingle | Bernhard Theodor Baune Tracy Air Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) Frontiers in Psychiatry Depression social cognition Cognitive Function Genomic biomarkers Cognitive Dimensions Biological correlates |
| title | Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) |
| title_full | Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) |
| title_fullStr | Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) |
| title_full_unstemmed | Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) |
| title_short | Clinical, functional and biological correlates of cognitive dimensions in major depressive disorder - rationale, design, and characteristics of the Cognitive Function and Mood Study (CoFaM-Study) |
| title_sort | clinical functional and biological correlates of cognitive dimensions in major depressive disorder rationale design and characteristics of the cognitive function and mood study cofam study |
| topic | Depression social cognition Cognitive Function Genomic biomarkers Cognitive Dimensions Biological correlates |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2016.00150/full |
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