Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.
CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the m...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2007-01-01
|
| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/4558 |
| _version_ | 1818034611813351424 |
|---|---|
| author | Agnieszka Kinsner Sandra Coecke Iwona Grabska-Liberek Grzegorz Wilczyński Aleksander Wasiutyński Dariusz Sladowski Iwona Kochanowska |
| author_facet | Agnieszka Kinsner Sandra Coecke Iwona Grabska-Liberek Grzegorz Wilczyński Aleksander Wasiutyński Dariusz Sladowski Iwona Kochanowska |
| author_sort | Agnieszka Kinsner |
| collection | DOAJ |
| description | CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans. |
| first_indexed | 2024-12-10T06:41:55Z |
| format | Article |
| id | doaj.art-f4d4142c4b95419e9e1f95a26d4e0293 |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-12-10T06:41:55Z |
| publishDate | 2007-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-f4d4142c4b95419e9e1f95a26d4e02932022-12-22T01:58:45ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312007-01-0144426326710.5603/4558Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.Agnieszka KinsnerSandra CoeckeIwona Grabska-LiberekGrzegorz WilczyńskiAleksander WasiutyńskiDariusz SladowskiIwona KochanowskaCD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans.http://czasopisma.viamedica.pl/fhc/article/view/4558 |
| spellingShingle | Agnieszka Kinsner Sandra Coecke Iwona Grabska-Liberek Grzegorz Wilczyński Aleksander Wasiutyński Dariusz Sladowski Iwona Kochanowska Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. Folia Histochemica et Cytobiologica |
| title | Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. |
| title_full | Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. |
| title_fullStr | Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. |
| title_full_unstemmed | Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. |
| title_short | Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus. |
| title_sort | expression of the membrane complement regulatory proteins cd55 and cd59 in human thymus |
| url | http://czasopisma.viamedica.pl/fhc/article/view/4558 |
| work_keys_str_mv | AT agnieszkakinsner expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT sandracoecke expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT iwonagrabskaliberek expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT grzegorzwilczynski expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT aleksanderwasiutynski expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT dariuszsladowski expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus AT iwonakochanowska expressionofthemembranecomplementregulatoryproteinscd55andcd59inhumanthymus |