Autophagy in Cancer Cell Death
Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/8/4/82 |
| _version_ | 1797716360203075584 |
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| author | Benedikt Linder Donat Kögel |
| author_facet | Benedikt Linder Donat Kögel |
| author_sort | Benedikt Linder |
| collection | DOAJ |
| description | Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of autophagy in cell survival and cell death decisions is highly dependent on its extent, duration, and on the respective cellular context. An alternative pro-death function of autophagy has been consistently observed in different settings, in particular, in developmental cell death of lower organisms and in drug-induced cancer cell death. This cell death is referred to as autophagic cell death (ACD) or autophagy-dependent cell death (ADCD), a type of cellular demise that may act as a backup cell death program in apoptosis-deficient tumors. This pro-death function of autophagy may be exerted either via non-selective bulk autophagy or excessive (lethal) removal of mitochondria via selective mitophagy, opening new avenues for the therapeutic exploitation of autophagy/mitophagy in cancer treatment. |
| first_indexed | 2024-03-12T08:20:17Z |
| format | Article |
| id | doaj.art-f4d47273173743ab8184626f667706cb |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T08:20:17Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-f4d47273173743ab8184626f667706cb2023-09-02T18:34:42ZengMDPI AGBiology2079-77372019-10-01848210.3390/biology8040082biology8040082Autophagy in Cancer Cell DeathBenedikt Linder0Donat Kögel1Experimental Neurosurgery, Department of Neurosurgery, Neuroscience Center, Goethe University Hospital, 60528 Frankfurt am Main, GermanyExperimental Neurosurgery, Department of Neurosurgery, Neuroscience Center, Goethe University Hospital, 60528 Frankfurt am Main, GermanyAutophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of autophagy in cell survival and cell death decisions is highly dependent on its extent, duration, and on the respective cellular context. An alternative pro-death function of autophagy has been consistently observed in different settings, in particular, in developmental cell death of lower organisms and in drug-induced cancer cell death. This cell death is referred to as autophagic cell death (ACD) or autophagy-dependent cell death (ADCD), a type of cellular demise that may act as a backup cell death program in apoptosis-deficient tumors. This pro-death function of autophagy may be exerted either via non-selective bulk autophagy or excessive (lethal) removal of mitochondria via selective mitophagy, opening new avenues for the therapeutic exploitation of autophagy/mitophagy in cancer treatment.https://www.mdpi.com/2079-7737/8/4/82autophagycell deathcancergossypolat-101mitophagymitochondria |
| spellingShingle | Benedikt Linder Donat Kögel Autophagy in Cancer Cell Death Biology autophagy cell death cancer gossypol at-101 mitophagy mitochondria |
| title | Autophagy in Cancer Cell Death |
| title_full | Autophagy in Cancer Cell Death |
| title_fullStr | Autophagy in Cancer Cell Death |
| title_full_unstemmed | Autophagy in Cancer Cell Death |
| title_short | Autophagy in Cancer Cell Death |
| title_sort | autophagy in cancer cell death |
| topic | autophagy cell death cancer gossypol at-101 mitophagy mitochondria |
| url | https://www.mdpi.com/2079-7737/8/4/82 |
| work_keys_str_mv | AT benediktlinder autophagyincancercelldeath AT donatkogel autophagyincancercelldeath |