Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature
IntroductionDespite the use of technology, recurrent diabetic ketoacidosis (DKA) prevention remains an unmet need in children and adolescents with T1D and may be accompanied by life-threatening acute complications. We present a rare case of non-occlusive mesenteric ischemia (NOMI) with overt manifes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.900325/full |
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| author | Giulio Frontino Giulio Frontino Raffaella Di Tonno Raffaella Di Tonno Valeria Castorani Valeria Castorani Andrea Rigamonti Andrea Rigamonti Elisa Morotti Elisa Morotti Federica Sandullo Federica Sandullo Francesco Scialabba Francesco Scialabba Francesca Arrigoni Francesca Arrigoni Riccardo Foglino Riccardo Foglino Benedetta Dionisi Benedetta Dionisi Chiara Irene Carla Ferri Salvatore Zirpoli Graziano Barera Franco Meschi Franco Meschi Riccardo Bonfanti Riccardo Bonfanti Riccardo Bonfanti |
| author_facet | Giulio Frontino Giulio Frontino Raffaella Di Tonno Raffaella Di Tonno Valeria Castorani Valeria Castorani Andrea Rigamonti Andrea Rigamonti Elisa Morotti Elisa Morotti Federica Sandullo Federica Sandullo Francesco Scialabba Francesco Scialabba Francesca Arrigoni Francesca Arrigoni Riccardo Foglino Riccardo Foglino Benedetta Dionisi Benedetta Dionisi Chiara Irene Carla Ferri Salvatore Zirpoli Graziano Barera Franco Meschi Franco Meschi Riccardo Bonfanti Riccardo Bonfanti Riccardo Bonfanti |
| author_sort | Giulio Frontino |
| collection | DOAJ |
| description | IntroductionDespite the use of technology, recurrent diabetic ketoacidosis (DKA) prevention remains an unmet need in children and adolescents with T1D and may be accompanied by life-threatening acute complications. We present a rare case of non-occlusive mesenteric ischemia (NOMI) with overt manifestation after DKA resolution and a discussion of recent literature addressing DKA-associated NOMI epidemiology and pathogenesis in children and adolescents.Case PresentationA 13-year-old female with previously diagnosed T1D, was admitted at our emergency department with hypovolemic shock, DKA, hyperosmolar state and acute kidney injury (AKI). Mildly progressive abdominal pain persisted after DKA correction and after repeated ultrasound evaluations ultimately suspect for intestinal perforation, an intraoperative diagnosis of NOMI was made.ConclusionThe diagnosis of DKA-associated NOMI must be suspected in pediatric patients with DKA, persistent abdominal pain, and severe dehydration even after DKA resolution. |
| first_indexed | 2024-04-12T07:10:01Z |
| format | Article |
| id | doaj.art-f4d5bd07237a482c975236f4b4486af3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T07:10:01Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f4d5bd07237a482c975236f4b4486af32022-12-22T03:42:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.900325900325Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of LiteratureGiulio Frontino0Giulio Frontino1Raffaella Di Tonno2Raffaella Di Tonno3Valeria Castorani4Valeria Castorani5Andrea Rigamonti6Andrea Rigamonti7Elisa Morotti8Elisa Morotti9Federica Sandullo10Federica Sandullo11Francesco Scialabba12Francesco Scialabba13Francesca Arrigoni14Francesca Arrigoni15Riccardo Foglino16Riccardo Foglino17Benedetta Dionisi18Benedetta Dionisi19Chiara Irene Carla Ferri20Salvatore Zirpoli21Graziano Barera22Franco Meschi23Franco Meschi24Riccardo Bonfanti25Riccardo Bonfanti26Riccardo Bonfanti27Department of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyPediatric Radiology and Neuroradiology, Children’s Hospital “V. Buzzi”, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pediatrics, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyIntroductionDespite the use of technology, recurrent diabetic ketoacidosis (DKA) prevention remains an unmet need in children and adolescents with T1D and may be accompanied by life-threatening acute complications. We present a rare case of non-occlusive mesenteric ischemia (NOMI) with overt manifestation after DKA resolution and a discussion of recent literature addressing DKA-associated NOMI epidemiology and pathogenesis in children and adolescents.Case PresentationA 13-year-old female with previously diagnosed T1D, was admitted at our emergency department with hypovolemic shock, DKA, hyperosmolar state and acute kidney injury (AKI). Mildly progressive abdominal pain persisted after DKA correction and after repeated ultrasound evaluations ultimately suspect for intestinal perforation, an intraoperative diagnosis of NOMI was made.ConclusionThe diagnosis of DKA-associated NOMI must be suspected in pediatric patients with DKA, persistent abdominal pain, and severe dehydration even after DKA resolution.https://www.frontiersin.org/articles/10.3389/fendo.2022.900325/fullnon-occlusive mesenteric ischemia (NOMI)DKA (diabetic ketoacidosis)insulin pump (CSII: continuous subcutaneous insulin infusion)acute kidney injuryhyperosmolar (hyperglycemic) comaT1DM (type 1 diabetes mellitus) |
| spellingShingle | Giulio Frontino Giulio Frontino Raffaella Di Tonno Raffaella Di Tonno Valeria Castorani Valeria Castorani Andrea Rigamonti Andrea Rigamonti Elisa Morotti Elisa Morotti Federica Sandullo Federica Sandullo Francesco Scialabba Francesco Scialabba Francesca Arrigoni Francesca Arrigoni Riccardo Foglino Riccardo Foglino Benedetta Dionisi Benedetta Dionisi Chiara Irene Carla Ferri Salvatore Zirpoli Graziano Barera Franco Meschi Franco Meschi Riccardo Bonfanti Riccardo Bonfanti Riccardo Bonfanti Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature Frontiers in Endocrinology non-occlusive mesenteric ischemia (NOMI) DKA (diabetic ketoacidosis) insulin pump (CSII: continuous subcutaneous insulin infusion) acute kidney injury hyperosmolar (hyperglycemic) coma T1DM (type 1 diabetes mellitus) |
| title | Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature |
| title_full | Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature |
| title_fullStr | Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature |
| title_full_unstemmed | Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature |
| title_short | Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature |
| title_sort | non occlusive mesenteric ischemia in children with diabetic ketoacidosis case report and review of literature |
| topic | non-occlusive mesenteric ischemia (NOMI) DKA (diabetic ketoacidosis) insulin pump (CSII: continuous subcutaneous insulin infusion) acute kidney injury hyperosmolar (hyperglycemic) coma T1DM (type 1 diabetes mellitus) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.900325/full |
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