POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION
The purpose of the study was to study the levels of placental growth factor (PlGF) and soluble receptor-1 vascular endothelial growth factor (sVEGF-R1) in the mother’s serum during normal pregnancy and pre-eclampsia developed before 34 weeks of pregnancy in the period 11–13 weeks. Material and metho...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-05-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/137 |
| _version_ | 1797269634137718784 |
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| author | L. D. Belotserkovtseva L. V. Kovalenko D. P. Telitsyn |
| author_facet | L. D. Belotserkovtseva L. V. Kovalenko D. P. Telitsyn |
| author_sort | L. D. Belotserkovtseva |
| collection | DOAJ |
| description | The purpose of the study was to study the levels of placental growth factor (PlGF) and soluble receptor-1 vascular endothelial growth factor (sVEGF-R1) in the mother’s serum during normal pregnancy and pre-eclampsia developed before 34 weeks of pregnancy in the period 11–13 weeks. Material and methods. In a prospective study, 95 patients were selected on the basis of risk factors for the development of pre-eclampsia in the first prenatal screen and further examined blood for PlGF and sVEGF-R1. According to the results of the course of pregnancy, the patients were divided into 4 groups: the first group – preeclampsia developed before the 34th week of pregnancy, the 2nd group – uncomplicated pregnancy, the 3rd group – pregnancy proceeding with fetoplacental insufficiency, the 4th group – pregnancy ending in preterm labor. Results and discussion. In women with preeclampsia that developed before the 34th week of gestation, the medians of sVEGF and PlGF were 2275 and 64.5 pg/ml, respectively, in pregnancy with placental insufficiency – 648.9 and 31.5 pg/ml, in pregnancy ending in preterm labor – 102.5 and 20 pg/ml, in uncomplicated pregnancy – 1170.0 and 34,5 pg/ml. The results can be used in the screening of the first trimester of pregnancy to predict various pathological conditions of pregnancy. |
| first_indexed | 2024-03-08T14:34:39Z |
| format | Article |
| id | doaj.art-f4d696b50f2e4facaa13dd1f85f0fa03 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:51:29Z |
| publishDate | 2019-05-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-f4d696b50f2e4facaa13dd1f85f0fa032024-03-07T18:49:57ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-05-01392818510.15372/SSMJ20190211130POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATIONL. D. Belotserkovtseva0L. V. Kovalenko1D. P. Telitsyn2Medical Institute of Surgut State UniversityMedical Institute of Surgut State UniversityMedical Institute of Surgut State UniversityThe purpose of the study was to study the levels of placental growth factor (PlGF) and soluble receptor-1 vascular endothelial growth factor (sVEGF-R1) in the mother’s serum during normal pregnancy and pre-eclampsia developed before 34 weeks of pregnancy in the period 11–13 weeks. Material and methods. In a prospective study, 95 patients were selected on the basis of risk factors for the development of pre-eclampsia in the first prenatal screen and further examined blood for PlGF and sVEGF-R1. According to the results of the course of pregnancy, the patients were divided into 4 groups: the first group – preeclampsia developed before the 34th week of pregnancy, the 2nd group – uncomplicated pregnancy, the 3rd group – pregnancy proceeding with fetoplacental insufficiency, the 4th group – pregnancy ending in preterm labor. Results and discussion. In women with preeclampsia that developed before the 34th week of gestation, the medians of sVEGF and PlGF were 2275 and 64.5 pg/ml, respectively, in pregnancy with placental insufficiency – 648.9 and 31.5 pg/ml, in pregnancy ending in preterm labor – 102.5 and 20 pg/ml, in uncomplicated pregnancy – 1170.0 and 34,5 pg/ml. The results can be used in the screening of the first trimester of pregnancy to predict various pathological conditions of pregnancy.https://sibmed.elpub.ru/jour/article/view/137early preeclampsiapreterm laborplacental insufficiencyplacental growth factorsoluble receptor-1 vascular endothelial factor |
| spellingShingle | L. D. Belotserkovtseva L. V. Kovalenko D. P. Telitsyn POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION Сибирский научный медицинский журнал early preeclampsia preterm labor placental insufficiency placental growth factor soluble receptor-1 vascular endothelial factor |
| title | POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION |
| title_full | POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION |
| title_fullStr | POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION |
| title_full_unstemmed | POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION |
| title_short | POSSIBILITIES OF FORECASTING EARLY PREECLAMPSIA IN 11-13 WEEK OF GESTATION |
| title_sort | possibilities of forecasting early preeclampsia in 11 13 week of gestation |
| topic | early preeclampsia preterm labor placental insufficiency placental growth factor soluble receptor-1 vascular endothelial factor |
| url | https://sibmed.elpub.ru/jour/article/view/137 |
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