Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia?
Abstract Preeclampsia (PE) occurs only in humans and some non‐human primates, making its pathogenesis difficult to study. The aetiology of PE is mainly caused by a deficiency in trophoblast differentiation and spiral artery remodelling. The angiogenic factor Placental Growth Factor (PlGF) or the rat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.76 |
| _version_ | 1797945506663497728 |
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| author | Wenna Chi Yuming Zhang Jinliang Yang Ligong Chen |
| author_facet | Wenna Chi Yuming Zhang Jinliang Yang Ligong Chen |
| author_sort | Wenna Chi |
| collection | DOAJ |
| description | Abstract Preeclampsia (PE) occurs only in humans and some non‐human primates, making its pathogenesis difficult to study. The aetiology of PE is mainly caused by a deficiency in trophoblast differentiation and spiral artery remodelling. The angiogenic factor Placental Growth Factor (PlGF) or the ratio of sFlt‐1 to PlGF and cell‐free RNA have been used as the main biomarkers for predicting PE. Now, Lee and colleagues show that the deficiency of cluster of differentiation 147 (CD147) results in preeclampsia pathophysiology. This contribution makes sheds light on PE development and unveils CD147 as a potential biomarker for clinical trials. |
| first_indexed | 2024-04-10T20:56:13Z |
| format | Article |
| id | doaj.art-f4d8ad2a4dc74c6eb11ee63066bfc936 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-10T20:56:13Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-f4d8ad2a4dc74c6eb11ee63066bfc9362023-01-23T05:21:29ZengWileyClinical and Translational Discovery2768-06222022-06-0122n/an/a10.1002/ctd2.76Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia?Wenna Chi0Yuming Zhang1Jinliang Yang2Ligong Chen3School of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Tsinghua University Beijing ChinaSchool of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Tsinghua University Beijing ChinaCollaborative Innovation Center for Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University Chengdu ChinaSchool of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Tsinghua University Beijing ChinaAbstract Preeclampsia (PE) occurs only in humans and some non‐human primates, making its pathogenesis difficult to study. The aetiology of PE is mainly caused by a deficiency in trophoblast differentiation and spiral artery remodelling. The angiogenic factor Placental Growth Factor (PlGF) or the ratio of sFlt‐1 to PlGF and cell‐free RNA have been used as the main biomarkers for predicting PE. Now, Lee and colleagues show that the deficiency of cluster of differentiation 147 (CD147) results in preeclampsia pathophysiology. This contribution makes sheds light on PE development and unveils CD147 as a potential biomarker for clinical trials.https://doi.org/10.1002/ctd2.76CD147preeclampsiaspiral artery remodellingtrophoblast differentiation |
| spellingShingle | Wenna Chi Yuming Zhang Jinliang Yang Ligong Chen Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? Clinical and Translational Discovery CD147 preeclampsia spiral artery remodelling trophoblast differentiation |
| title | Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? |
| title_full | Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? |
| title_fullStr | Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? |
| title_full_unstemmed | Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? |
| title_short | Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia? |
| title_sort | cluster of differentiation 147 complex a putative early predictive biomarker for preeclampsia |
| topic | CD147 preeclampsia spiral artery remodelling trophoblast differentiation |
| url | https://doi.org/10.1002/ctd2.76 |
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