Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease
Diabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with diabetes and its prevalence is increasing worldwide. It encompasses histological alterations that mainly affect the glomerular filtration unit, which include thickening of the basement membrane, mesangial c...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182300066X |
| _version_ | 1797448158867881984 |
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| author | Adriana Petrazzuolo Gianmarco Sabiu Emma Assi Anna Maestroni Ida Pastore Maria Elena Lunati Laura Montefusco Cristian Loretelli Giada Rossi Moufida Ben Nasr Vera Usuelli Yanan Xie Hari Baskar Balasubramanian Monica Zocchi Basset El Essawy Jun Yang Francesca D’Addio Paolo Fiorina |
| author_facet | Adriana Petrazzuolo Gianmarco Sabiu Emma Assi Anna Maestroni Ida Pastore Maria Elena Lunati Laura Montefusco Cristian Loretelli Giada Rossi Moufida Ben Nasr Vera Usuelli Yanan Xie Hari Baskar Balasubramanian Monica Zocchi Basset El Essawy Jun Yang Francesca D’Addio Paolo Fiorina |
| author_sort | Adriana Petrazzuolo |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with diabetes and its prevalence is increasing worldwide. It encompasses histological alterations that mainly affect the glomerular filtration unit, which include thickening of the basement membrane, mesangial cell proliferation, endothelial alteration, and podocyte injury. These morphological abnormalities further result in a persistent increase of urinary albumin-to-creatinine ratio and in a reduction of the estimated glomerular filtration rate. Several molecular and cellular mechanisms have been recognized, up to date, as major players in mediating such clinical and histological features and many more are being under investigation. This review summarizes the most recent advances in understanding cell death mechanisms, intracellular signaling pathways and molecular effectors that play a role in the onset and progression of diabetic kidney damage. Some of those molecular and cellular mechanisms have been already successfully targeted in preclinical models of DKD and, in some cases, strategies have been tested in clinical trials. Finally, this report sheds light on the relevance of novel pathways that may become therapeutic targets for future applications in DKD. |
| first_indexed | 2024-03-09T14:06:26Z |
| format | Article |
| id | doaj.art-f4d913eb8c7b477ba0c24bf7919d6299 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-09T14:06:26Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-f4d913eb8c7b477ba0c24bf7919d62992023-11-30T05:05:53ZengElsevierPharmacological Research1096-11862023-04-01190106710Broadening horizons in mechanisms, management, and treatment of diabetic kidney diseaseAdriana Petrazzuolo0Gianmarco Sabiu1Emma Assi2Anna Maestroni3Ida Pastore4Maria Elena Lunati5Laura Montefusco6Cristian Loretelli7Giada Rossi8Moufida Ben Nasr9Vera Usuelli10Yanan Xie11Hari Baskar Balasubramanian12Monica Zocchi13Basset El Essawy14Jun Yang15Francesca D’Addio16Paolo Fiorina17International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Boston Children’s Hospital and Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyDivision of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, ItalyDivision of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, ItalyDivision of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Boston Children’s Hospital and Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China; NHC Key Laboratory of Organ Transplantation, Wuhan, China; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyMedicine, Al-Azhar University, Cairo, Egypt; Renal Division, Brigham and Women's Hospital, Boston, MAKey Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China; NHC Key Laboratory of Organ Transplantation, Wuhan, China; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy; Corresponding authors at: International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyInternational Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, Italy; Boston Children’s Hospital and Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy; Corresponding authors at: International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università degli Studi di Milano, Milan, ItalyDiabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with diabetes and its prevalence is increasing worldwide. It encompasses histological alterations that mainly affect the glomerular filtration unit, which include thickening of the basement membrane, mesangial cell proliferation, endothelial alteration, and podocyte injury. These morphological abnormalities further result in a persistent increase of urinary albumin-to-creatinine ratio and in a reduction of the estimated glomerular filtration rate. Several molecular and cellular mechanisms have been recognized, up to date, as major players in mediating such clinical and histological features and many more are being under investigation. This review summarizes the most recent advances in understanding cell death mechanisms, intracellular signaling pathways and molecular effectors that play a role in the onset and progression of diabetic kidney damage. Some of those molecular and cellular mechanisms have been already successfully targeted in preclinical models of DKD and, in some cases, strategies have been tested in clinical trials. Finally, this report sheds light on the relevance of novel pathways that may become therapeutic targets for future applications in DKD.http://www.sciencedirect.com/science/article/pii/S104366182300066XDiabetic kidney diseaseDiabetesPodocytesGlomerular cells |
| spellingShingle | Adriana Petrazzuolo Gianmarco Sabiu Emma Assi Anna Maestroni Ida Pastore Maria Elena Lunati Laura Montefusco Cristian Loretelli Giada Rossi Moufida Ben Nasr Vera Usuelli Yanan Xie Hari Baskar Balasubramanian Monica Zocchi Basset El Essawy Jun Yang Francesca D’Addio Paolo Fiorina Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease Pharmacological Research Diabetic kidney disease Diabetes Podocytes Glomerular cells |
| title | Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease |
| title_full | Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease |
| title_fullStr | Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease |
| title_full_unstemmed | Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease |
| title_short | Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease |
| title_sort | broadening horizons in mechanisms management and treatment of diabetic kidney disease |
| topic | Diabetic kidney disease Diabetes Podocytes Glomerular cells |
| url | http://www.sciencedirect.com/science/article/pii/S104366182300066X |
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