Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury
Kai Jia,1 Xin Tong,1 Fang Liang2 1Department of Nutrition, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; 2Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China Objective: To investigate the effects of sequent...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-06-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/effects-of-sequential-nutritional-support-on-nutritional-status-and-ex-peer-reviewed-article-NDT |
| _version_ | 1818684646098993152 |
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| author | Jia K Tong X Liang F |
| author_facet | Jia K Tong X Liang F |
| author_sort | Jia K |
| collection | DOAJ |
| description | Kai Jia,1 Xin Tong,1 Fang Liang2 1Department of Nutrition, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; 2Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China Objective: To investigate the effects of sequential nutritional support on nutritional status and immune regulation in patients with early severe traumatic brain injury (STBI). Patients and methods: A total of 62 patients diagnosed with STBI enrolled from Chaoyang Hospital (Beijing, China) from February 2015 to October 2016 were divided into two groups. The observational group (n=34) was given sequential nutritional support and the control group (n=28) was given the standard formula of whole protein enteral preparations. The energy supply for the two groups was 30 kcal/kg/d and protein 1.6 g/kg/d, respectively. The albumin (ALB), total protein (TP), high-sensitivity C-reactive protein (Hs-CRP), neuron-specific enolase (NSE), Glasgow Coma Score (GCS), and regulatory T cells before and after nutritional treatment were measured in both groups. Results: At the 14th day, the levels of ALB (41.7±4.2 g/L) and TP (70.6±4.9 g/L) were significantly higher than those in the control group (33.5±2.3 g/L and 62.3±3.9 g/L) (P<0.05). The levels of Hs-CRP and NSE were significantly lower in the observational group (0.96±0.82 mg/L and 11.96±7.82 ng/L) than in the control group (1.17±0.74 mg/L and 19.17±6.74 ng/L) (P<0.05). The GCS score in the observational group (11.5±2.9) was significantly higher than that in the control group (8.1±1.7) (P<0.05). The percentage of Tregs in the peripheral CD4+ lymphocytes was significantly lower in the observational group than in the control group (P<0.05). Conclusion: The effect of sequential nutritional support is better than conventional nutritional support in patients with STBI. The findings call for early identification of malnutrition and individual nutritional support. Keywords: severe traumatic brain injury, enteral nutrition, sequential nutrition, regulatory T lymphocytes |
| first_indexed | 2024-12-17T10:53:56Z |
| format | Article |
| id | doaj.art-f4da03e62d80477ea2b59925f12f211a |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-17T10:53:56Z |
| publishDate | 2018-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-f4da03e62d80477ea2b59925f12f211a2022-12-21T21:51:53ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212018-06-01Volume 141561156738823Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injuryJia KTong XLiang FKai Jia,1 Xin Tong,1 Fang Liang2 1Department of Nutrition, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; 2Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China Objective: To investigate the effects of sequential nutritional support on nutritional status and immune regulation in patients with early severe traumatic brain injury (STBI). Patients and methods: A total of 62 patients diagnosed with STBI enrolled from Chaoyang Hospital (Beijing, China) from February 2015 to October 2016 were divided into two groups. The observational group (n=34) was given sequential nutritional support and the control group (n=28) was given the standard formula of whole protein enteral preparations. The energy supply for the two groups was 30 kcal/kg/d and protein 1.6 g/kg/d, respectively. The albumin (ALB), total protein (TP), high-sensitivity C-reactive protein (Hs-CRP), neuron-specific enolase (NSE), Glasgow Coma Score (GCS), and regulatory T cells before and after nutritional treatment were measured in both groups. Results: At the 14th day, the levels of ALB (41.7±4.2 g/L) and TP (70.6±4.9 g/L) were significantly higher than those in the control group (33.5±2.3 g/L and 62.3±3.9 g/L) (P<0.05). The levels of Hs-CRP and NSE were significantly lower in the observational group (0.96±0.82 mg/L and 11.96±7.82 ng/L) than in the control group (1.17±0.74 mg/L and 19.17±6.74 ng/L) (P<0.05). The GCS score in the observational group (11.5±2.9) was significantly higher than that in the control group (8.1±1.7) (P<0.05). The percentage of Tregs in the peripheral CD4+ lymphocytes was significantly lower in the observational group than in the control group (P<0.05). Conclusion: The effect of sequential nutritional support is better than conventional nutritional support in patients with STBI. The findings call for early identification of malnutrition and individual nutritional support. Keywords: severe traumatic brain injury, enteral nutrition, sequential nutrition, regulatory T lymphocyteshttps://www.dovepress.com/effects-of-sequential-nutritional-support-on-nutritional-status-and-ex-peer-reviewed-article-NDTsevere traumatic brain injuryenteral nutritionsequential nutritionregulatory T lymphocytes |
| spellingShingle | Jia K Tong X Liang F Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury Neuropsychiatric Disease and Treatment severe traumatic brain injury enteral nutrition sequential nutrition regulatory T lymphocytes |
| title | Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury |
| title_full | Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury |
| title_fullStr | Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury |
| title_full_unstemmed | Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury |
| title_short | Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury |
| title_sort | effects of sequential nutritional support on nutritional status and expression of regulatory t lymphocyte in patients with early severe traumatic brain injury |
| topic | severe traumatic brain injury enteral nutrition sequential nutrition regulatory T lymphocytes |
| url | https://www.dovepress.com/effects-of-sequential-nutritional-support-on-nutritional-status-and-ex-peer-reviewed-article-NDT |
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