Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic
<abstract language="eng">It is the specific treatment of mansoni schistosomiasis that aims to act directed on the parasite, through chemotherapy. Constitutes fundamental indication to the treatment of schistosomiasis active forms, that is, these determined by the presence of living e...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1992-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800055 |
| _version_ | 1797704697159614464 |
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| author | Aloisio Sales da Cunha |
| author_facet | Aloisio Sales da Cunha |
| author_sort | Aloisio Sales da Cunha |
| collection | DOAJ |
| description | <abstract language="eng">It is the specific treatment of mansoni schistosomiasis that aims to act directed on the parasite, through chemotherapy. Constitutes fundamental indication to the treatment of schistosomiasis active forms, that is, these determined by the presence of living eggs in the feces or in material from rectal biopsy, since eventual contra indications are respected. Two are the medicaments actually used: oxamniquine, used in the single dosage of 15mg/kg, V.O. for adults and 20mg/kg V.O. for children divided in two doses, offers a percentage of 30 to 40% of cures, evaluated by quantitative "oogram" and prazinquantel, in the single dose of 60 mg/kg V.O., presents a cure index of 30% however in seriate doses, of 60mg/kg during 3 days or 30mg/kg, 6 days, cure percentage is elevated to 95% evaluated by oogram. The evaluation of the treatment by quantitative or qualitative examination methods does not show the same sensibility. The percentage of cure according to feces examination, the quantitative of Kato-Katz or the qualitative (sedimentation), showed indexes from 90 to 100% for either one of the drugs, even in single dose, which evidences the difference of methodology of therapeutic evaluation. Tolorance to both medicaments is from good to regular, with collateral effects in 30 to 40% of the patients. |
| first_indexed | 2024-03-12T05:24:18Z |
| format | Article |
| id | doaj.art-f4dfed62fb324c5c8a34a4b78be9c4af |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:24:18Z |
| publishDate | 1992-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-f4dfed62fb324c5c8a34a4b78be9c4af2023-09-03T07:27:15ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601992-01-018734135110.1590/S0074-02761992000800055Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeuticAloisio Sales da Cunha<abstract language="eng">It is the specific treatment of mansoni schistosomiasis that aims to act directed on the parasite, through chemotherapy. Constitutes fundamental indication to the treatment of schistosomiasis active forms, that is, these determined by the presence of living eggs in the feces or in material from rectal biopsy, since eventual contra indications are respected. Two are the medicaments actually used: oxamniquine, used in the single dosage of 15mg/kg, V.O. for adults and 20mg/kg V.O. for children divided in two doses, offers a percentage of 30 to 40% of cures, evaluated by quantitative "oogram" and prazinquantel, in the single dose of 60 mg/kg V.O., presents a cure index of 30% however in seriate doses, of 60mg/kg during 3 days or 30mg/kg, 6 days, cure percentage is elevated to 95% evaluated by oogram. The evaluation of the treatment by quantitative or qualitative examination methods does not show the same sensibility. The percentage of cure according to feces examination, the quantitative of Kato-Katz or the qualitative (sedimentation), showed indexes from 90 to 100% for either one of the drugs, even in single dose, which evidences the difference of methodology of therapeutic evaluation. Tolorance to both medicaments is from good to regular, with collateral effects in 30 to 40% of the patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800055chemotherapyoxamniquinetherapeutic evaluation |
| spellingShingle | Aloisio Sales da Cunha Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic Memorias do Instituto Oswaldo Cruz chemotherapy oxamniquine therapeutic evaluation |
| title | Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic |
| title_full | Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic |
| title_fullStr | Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic |
| title_full_unstemmed | Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic |
| title_short | Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic |
| title_sort | esquistossomose mansoni tratamento medicamentoso schistosomiasis mansoni drug therapeutic |
| topic | chemotherapy oxamniquine therapeutic evaluation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800055 |
| work_keys_str_mv | AT aloisiosalesdacunha esquistossomosemansonitratamentomedicamentososchistosomiasismansonidrugtherapeutic |