Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing
Abstract Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic CDs with antimicrobial activity have appeared. In the present work, we engineered...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01572-w |
| _version_ | 1798037750903996416 |
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| author | Chengjian Mou Xinyuan Wang Jiahui Teng Zhigang Xie Min Zheng |
| author_facet | Chengjian Mou Xinyuan Wang Jiahui Teng Zhigang Xie Min Zheng |
| author_sort | Chengjian Mou |
| collection | DOAJ |
| description | Abstract Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic CDs with antimicrobial activity have appeared. In the present work, we engineered a string of anionic CDs (especially CD31) as valid broad-spectrum bactericides to kill bacteria. Furthermore, CD31 conjugated with ɛ-polylysine (Plys) to construct injectable, and self-healing hydrogel (CD-Plys) that possess the advantages of remarkable broad spectrum antibacterial activity, excellent wound healing ability and satisfied biocompatibility. CD-Plys could dramatically accelerate wound healing with epithelization and enhanced angiogenesis. Taken together, this work provides a two-pronged strategy to explore CDs-based antimicrobial agents for disease therapy and tissue engineering. |
| first_indexed | 2024-04-11T21:30:49Z |
| format | Article |
| id | doaj.art-f4e094d2655742309d1d8ec0a396c2cf |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T21:30:49Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-f4e094d2655742309d1d8ec0a396c2cf2022-12-22T04:02:00ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120111310.1186/s12951-022-01572-wInjectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healingChengjian Mou0Xinyuan Wang1Jiahui Teng2Zhigang Xie3Min Zheng4School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of TechnologySchool of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of TechnologySchool of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of TechnologyState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of SciencesSchool of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of TechnologyAbstract Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic CDs with antimicrobial activity have appeared. In the present work, we engineered a string of anionic CDs (especially CD31) as valid broad-spectrum bactericides to kill bacteria. Furthermore, CD31 conjugated with ɛ-polylysine (Plys) to construct injectable, and self-healing hydrogel (CD-Plys) that possess the advantages of remarkable broad spectrum antibacterial activity, excellent wound healing ability and satisfied biocompatibility. CD-Plys could dramatically accelerate wound healing with epithelization and enhanced angiogenesis. Taken together, this work provides a two-pronged strategy to explore CDs-based antimicrobial agents for disease therapy and tissue engineering.https://doi.org/10.1186/s12951-022-01572-wHydrogelNegatively charged carbon dotsAntibacterialWound healingɛ-polylysine |
| spellingShingle | Chengjian Mou Xinyuan Wang Jiahui Teng Zhigang Xie Min Zheng Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing Journal of Nanobiotechnology Hydrogel Negatively charged carbon dots Antibacterial Wound healing ɛ-polylysine |
| title | Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing |
| title_full | Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing |
| title_fullStr | Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing |
| title_full_unstemmed | Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing |
| title_short | Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing |
| title_sort | injectable self healing hydrogel fabricated from antibacterial carbon dots and e polylysine for promoting bacteria infected wound healing |
| topic | Hydrogel Negatively charged carbon dots Antibacterial Wound healing ɛ-polylysine |
| url | https://doi.org/10.1186/s12951-022-01572-w |
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