Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients

Inflammation induced by traumatic brain injury (TBI) is complex, individual-specific, and associated with morbidity and mortality. We sought to develop dynamic, data-driven, predictive computational models of TBI-induced inflammation based on cerebrospinal fluid (CSF) biomarkers. Thirteen inflammat...

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Bibliographic Details
Main Authors: Gregory Constantine, Marius Buliga, Qi Mi, Florica Constantine, Andrew Abboud, Ruben Zamora, Ava Puccio, David Okonkwo, Yoram Vodovotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
Inflammation
mathematical modeling
TBI
precision medicine
TBI outcome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00383/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00383/full

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