Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology
Tripterygium hypoglaucum (Levl.) Hutch (THH) is the source plant of a traditional Chinese medicine named Kunmingshanhaitang, which was first recorded in Compendium of Materia Medica. Like Tripterygium wilfordii Hook f. (TWH), THH is also widely used in the treatment of various autoimmune diseases, s...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522000550 |
| _version_ | 1811336666889060352 |
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| author | Jiangping Wei Liyun Chen Sijia Gao Jirui Wang Yunhong Wang Zhiwei Zhang Yuyu Zhang Xiaomei Zhang Yong Yang Dajian Yang |
| author_facet | Jiangping Wei Liyun Chen Sijia Gao Jirui Wang Yunhong Wang Zhiwei Zhang Yuyu Zhang Xiaomei Zhang Yong Yang Dajian Yang |
| author_sort | Jiangping Wei |
| collection | DOAJ |
| description | Tripterygium hypoglaucum (Levl.) Hutch (THH) is the source plant of a traditional Chinese medicine named Kunmingshanhaitang, which was first recorded in Compendium of Materia Medica. Like Tripterygium wilfordii Hook f. (TWH), THH is also widely used in the treatment of various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and psoriasis. The therapeutic effect of THH is closely related to its special compound composition. By now, about 300 compounds have been isolated and identified from THH, including sesquiterpenoids, diterpenoids, triterpenoids, flavonoids, lignans, alkaloids, fatty acids, steroids and others. Further studies found that many compounds originated from THH showed a wide range of biological activities, such as immunosuppression, anti-inflammatory, antitumor, neuroprotection and the others. It is worth noting that THH belongs to the toxic traditional Chinese medicine, commonly known as gut-break grass. Although there have been a lot of studies on the toxic doses of some extracts or isolated compounds of THH, their mechanism remains unclear. Further study on the structure and function relationship of each active and/or toxic compound, analysis of their unique mechanism of action or toxicity mechanism, and exploration of its detoxification methods and new clinical uses will contribute to its better use for human health. In order to better explore the pharmaceutical potential of THH, this paper systematically reviewed its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, toxicology and detoxification, which is convenient for further understanding and research. |
| first_indexed | 2024-04-13T17:42:55Z |
| format | Article |
| id | doaj.art-f4e374daacab483ab7852d21a4506329 |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-04-13T17:42:55Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-f4e374daacab483ab7852d21a45063292022-12-22T02:37:07ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-06-013100094Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicologyJiangping Wei0Liyun Chen1Sijia Gao2Jirui Wang3Yunhong Wang4Zhiwei Zhang5Yuyu Zhang6Xiaomei Zhang7Yong Yang8Dajian Yang9Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China; College of Pharmacy, Chong Qing Medical University, Chongqing 400016, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, China; College of Pharmacy, Southwest University, Chongqing 400715, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaChongqing Academy of Chinese Materia Medica, Chongqing 400065, China; Corresponding authors.Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China; Corresponding authors.Chongqing Academy of Chinese Materia Medica, Chongqing 400065, ChinaTripterygium hypoglaucum (Levl.) Hutch (THH) is the source plant of a traditional Chinese medicine named Kunmingshanhaitang, which was first recorded in Compendium of Materia Medica. Like Tripterygium wilfordii Hook f. (TWH), THH is also widely used in the treatment of various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and psoriasis. The therapeutic effect of THH is closely related to its special compound composition. By now, about 300 compounds have been isolated and identified from THH, including sesquiterpenoids, diterpenoids, triterpenoids, flavonoids, lignans, alkaloids, fatty acids, steroids and others. Further studies found that many compounds originated from THH showed a wide range of biological activities, such as immunosuppression, anti-inflammatory, antitumor, neuroprotection and the others. It is worth noting that THH belongs to the toxic traditional Chinese medicine, commonly known as gut-break grass. Although there have been a lot of studies on the toxic doses of some extracts or isolated compounds of THH, their mechanism remains unclear. Further study on the structure and function relationship of each active and/or toxic compound, analysis of their unique mechanism of action or toxicity mechanism, and exploration of its detoxification methods and new clinical uses will contribute to its better use for human health. In order to better explore the pharmaceutical potential of THH, this paper systematically reviewed its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, toxicology and detoxification, which is convenient for further understanding and research.http://www.sciencedirect.com/science/article/pii/S2667142522000550Tripterygium hypoglaucum (Levl.) HutchPhytochemistryPharmacologyPharmacokineticsToxicologyDetoxification |
| spellingShingle | Jiangping Wei Liyun Chen Sijia Gao Jirui Wang Yunhong Wang Zhiwei Zhang Yuyu Zhang Xiaomei Zhang Yong Yang Dajian Yang Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology Pharmacological Research - Modern Chinese Medicine Tripterygium hypoglaucum (Levl.) Hutch Phytochemistry Pharmacology Pharmacokinetics Toxicology Detoxification |
| title | Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology |
| title_full | Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology |
| title_fullStr | Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology |
| title_full_unstemmed | Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology |
| title_short | Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology |
| title_sort | tripterygium hypoglaucum levl hutch a systematic review of its traditional uses botany phytochemistry pharmacology pharmacokinetics and toxicology |
| topic | Tripterygium hypoglaucum (Levl.) Hutch Phytochemistry Pharmacology Pharmacokinetics Toxicology Detoxification |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522000550 |
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