The Role of the Gut Microbiome in Liver Cirrhosis Treatment
Liver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing cholangitis and Wilson’s disease can also lead to cirrhosis. Moreover, alcohol can cause cirrhosis on its own and exacerba...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/1/199 |
| _version_ | 1797543403532058624 |
|---|---|
| author | Na Young Lee Ki Tae Suk |
| author_facet | Na Young Lee Ki Tae Suk |
| author_sort | Na Young Lee |
| collection | DOAJ |
| description | Liver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing cholangitis and Wilson’s disease can also lead to cirrhosis. Moreover, alcohol can cause cirrhosis on its own and exacerbate chronic liver disease of other causes. The treatment of cirrhosis can be divided into addressing the cause of cirrhosis and reversing liver fibrosis. To this date, there is still no clear consensus on the treatment of cirrhosis. Recently, there has been a lot of interest in potential treatments that modulate the gut microbiota and gut-liver axis for the treatment of cirrhosis. According to recent studies, modulation of the gut microbiome by probiotics ameliorates the progression of liver disease. The precise mechanism for relieving cirrhosis via gut microbial modulation has not been identified. This paper summarizes the role and effects of the gut microbiome in cirrhosis based on experimental and clinical studies on absorbable antibiotics, probiotics, prebiotics, and synbiotics. Moreover, it provides evidence of a relationship between the gut microbiome and liver fibrosis. |
| first_indexed | 2024-03-10T13:45:04Z |
| format | Article |
| id | doaj.art-f4e38e8c60d04020939a92810e8ac597 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:45:04Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4e38e8c60d04020939a92810e8ac5972023-11-21T02:45:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122119910.3390/ijms22010199The Role of the Gut Microbiome in Liver Cirrhosis TreatmentNa Young Lee0Ki Tae Suk1Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, KoreaInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, KoreaLiver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing cholangitis and Wilson’s disease can also lead to cirrhosis. Moreover, alcohol can cause cirrhosis on its own and exacerbate chronic liver disease of other causes. The treatment of cirrhosis can be divided into addressing the cause of cirrhosis and reversing liver fibrosis. To this date, there is still no clear consensus on the treatment of cirrhosis. Recently, there has been a lot of interest in potential treatments that modulate the gut microbiota and gut-liver axis for the treatment of cirrhosis. According to recent studies, modulation of the gut microbiome by probiotics ameliorates the progression of liver disease. The precise mechanism for relieving cirrhosis via gut microbial modulation has not been identified. This paper summarizes the role and effects of the gut microbiome in cirrhosis based on experimental and clinical studies on absorbable antibiotics, probiotics, prebiotics, and synbiotics. Moreover, it provides evidence of a relationship between the gut microbiome and liver fibrosis.https://www.mdpi.com/1422-0067/22/1/199liver cirrhosisliver fibrosisgut microbiomegut-liver axis |
| spellingShingle | Na Young Lee Ki Tae Suk The Role of the Gut Microbiome in Liver Cirrhosis Treatment International Journal of Molecular Sciences liver cirrhosis liver fibrosis gut microbiome gut-liver axis |
| title | The Role of the Gut Microbiome in Liver Cirrhosis Treatment |
| title_full | The Role of the Gut Microbiome in Liver Cirrhosis Treatment |
| title_fullStr | The Role of the Gut Microbiome in Liver Cirrhosis Treatment |
| title_full_unstemmed | The Role of the Gut Microbiome in Liver Cirrhosis Treatment |
| title_short | The Role of the Gut Microbiome in Liver Cirrhosis Treatment |
| title_sort | role of the gut microbiome in liver cirrhosis treatment |
| topic | liver cirrhosis liver fibrosis gut microbiome gut-liver axis |
| url | https://www.mdpi.com/1422-0067/22/1/199 |
| work_keys_str_mv | AT nayounglee theroleofthegutmicrobiomeinlivercirrhosistreatment AT kitaesuk theroleofthegutmicrobiomeinlivercirrhosistreatment AT nayounglee roleofthegutmicrobiomeinlivercirrhosistreatment AT kitaesuk roleofthegutmicrobiomeinlivercirrhosistreatment |