The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947
The LuxS protein, encoded by <i>luxS</i>, is required for the production of autoinducer 2 (AI-2) in <i>Streptococcus pneumoniae</i>. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/2/216 |
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| author | Alexandra Tikhomirova Erin B. Brazel Kimberley T. McLean Hannah N. Agnew James C. Paton Claudia Trappetti |
| author_facet | Alexandra Tikhomirova Erin B. Brazel Kimberley T. McLean Hannah N. Agnew James C. Paton Claudia Trappetti |
| author_sort | Alexandra Tikhomirova |
| collection | DOAJ |
| description | The LuxS protein, encoded by <i>luxS</i>, is required for the production of autoinducer 2 (AI-2) in <i>Streptococcus pneumoniae</i>. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. The role of <i>luxS</i> in <i>S. pneumoniae</i> biology and lifestyle has been predominantly assessed in the laboratory strain D39. However, as biofilm formation, which is regulated by <i>luxS</i>, is critical for the ability of <i>S. pneumoniae</i> to cause otitis media, we investigated the role of <i>luxS</i> in a middle ear isolate, strain 947. Our results identified <i>luxS</i> to have a role in prevention of <i>S. pneumoniae</i> transition from colonisation of the nasopharynx to the ear, and in facilitating adherence to host epithelial cells. |
| first_indexed | 2024-03-09T21:17:26Z |
| format | Article |
| id | doaj.art-f4e41ea4414940ccb18aec82d37031f1 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T21:17:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-f4e41ea4414940ccb18aec82d37031f12023-11-23T21:32:10ZengMDPI AGPathogens2076-08172022-02-0111221610.3390/pathogens11020216The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947Alexandra Tikhomirova0Erin B. Brazel1Kimberley T. McLean2Hannah N. Agnew3James C. Paton4Claudia Trappetti5Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaResearch Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaResearch Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaResearch Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaResearch Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaResearch Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, AustraliaThe LuxS protein, encoded by <i>luxS</i>, is required for the production of autoinducer 2 (AI-2) in <i>Streptococcus pneumoniae</i>. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. The role of <i>luxS</i> in <i>S. pneumoniae</i> biology and lifestyle has been predominantly assessed in the laboratory strain D39. However, as biofilm formation, which is regulated by <i>luxS</i>, is critical for the ability of <i>S. pneumoniae</i> to cause otitis media, we investigated the role of <i>luxS</i> in a middle ear isolate, strain 947. Our results identified <i>luxS</i> to have a role in prevention of <i>S. pneumoniae</i> transition from colonisation of the nasopharynx to the ear, and in facilitating adherence to host epithelial cells.https://www.mdpi.com/2076-0817/11/2/216<i>Streptococcus pneumoniae</i>quorum sensingbiofilmsotitis media |
| spellingShingle | Alexandra Tikhomirova Erin B. Brazel Kimberley T. McLean Hannah N. Agnew James C. Paton Claudia Trappetti The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 Pathogens <i>Streptococcus pneumoniae</i> quorum sensing biofilms otitis media |
| title | The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 |
| title_full | The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 |
| title_fullStr | The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 |
| title_full_unstemmed | The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 |
| title_short | The Role of <i>luxS</i> in the Middle Ear <i>Streptococcus pneumoniae</i> Isolate 947 |
| title_sort | role of i luxs i in the middle ear i streptococcus pneumoniae i isolate 947 |
| topic | <i>Streptococcus pneumoniae</i> quorum sensing biofilms otitis media |
| url | https://www.mdpi.com/2076-0817/11/2/216 |
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