Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages

Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages

Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively expressed by mammalian cells to regulate various cellular functions. It is associated with many diseases and is a potential therapeutic target. Although HSC70 also possesses an anti-inflammatory action, the mechanism of...

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Bibliographic Details
Main Authors:	Erna Sulistyowati, Mei-Yueh Lee, Lin-Chi Wu, Jong-Hau Hsu, Zen-Kong Dai, Bin-Nan Wu, Ming-Chung Lin, Jwu-Lai Yeh
Format:	Article
Language:	English
Published:	MDPI AG 2018-08-01
Series:	Molecules
Subjects:	heat shock protein lipopolysaccharide inflammation RAW264.7 macrophages matrix metalloproteinases
Online Access:	http://www.mdpi.com/1420-3049/23/9/2124

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