Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica
A proliferation inducing ligand (APRIL) mediates a key role in the generation and survival of antibody-inducing plasmocytes. Based on this, APRIL has been targeted in autoimmune diseases including multiple sclerosis (MS) and optic neuritis (ON). In MS lesions, APRIL has a new cellular target, the re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.721877/full |
| _version_ | 1819130617970819072 |
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| author | Laurie Baert Romain Marignier Hans P. Lassmann Bertrand Huard |
| author_facet | Laurie Baert Romain Marignier Hans P. Lassmann Bertrand Huard |
| author_sort | Laurie Baert |
| collection | DOAJ |
| description | A proliferation inducing ligand (APRIL) mediates a key role in the generation and survival of antibody-inducing plasmocytes. Based on this, APRIL has been targeted in autoimmune diseases including multiple sclerosis (MS) and optic neuritis (ON). In MS lesions, APRIL has a new cellular target, the reactive astrocyte and mediates an immunosuppressive activity. Here, we analyzed APRIL expression in a case of neuromyelitis optica (NMO), another autoimmune neurodegenerative disease, showing selective aquaporin-4 depletion in the spinal cord, complement deposition and infiltration of polymorphonuclear cells. We analyzed by immunohistochemistry the presence of APRIL-producing cells, plasmocytes, astrocytes and the localization of secreted APRIL in a lesion from NMO. Plasmocytes were present close to APRIL-producing cells in meninges. However, our main observation was that APRIL targets reactive astrocytes in this lesion of NMO similarly to MS. |
| first_indexed | 2024-12-22T09:02:28Z |
| format | Article |
| id | doaj.art-f4e4d98106ee4325bdf1401a763ae5cd |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T09:02:28Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f4e4d98106ee4325bdf1401a763ae5cd2022-12-21T18:31:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-08-011210.3389/fneur.2021.721877721877Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis OpticaLaurie Baert0Romain Marignier1Hans P. Lassmann2Bertrand Huard3Institute for Advanced Biosciences, University Grenoble-Alpes, Grenoble, FranceMIRCEM, P. Wertheimer Neurology Hospital, Lyon, FranceCenter for Brain Research, Medical University, Vienna, AustriaInstitute for Advanced Biosciences, University Grenoble-Alpes, Grenoble, FranceA proliferation inducing ligand (APRIL) mediates a key role in the generation and survival of antibody-inducing plasmocytes. Based on this, APRIL has been targeted in autoimmune diseases including multiple sclerosis (MS) and optic neuritis (ON). In MS lesions, APRIL has a new cellular target, the reactive astrocyte and mediates an immunosuppressive activity. Here, we analyzed APRIL expression in a case of neuromyelitis optica (NMO), another autoimmune neurodegenerative disease, showing selective aquaporin-4 depletion in the spinal cord, complement deposition and infiltration of polymorphonuclear cells. We analyzed by immunohistochemistry the presence of APRIL-producing cells, plasmocytes, astrocytes and the localization of secreted APRIL in a lesion from NMO. Plasmocytes were present close to APRIL-producing cells in meninges. However, our main observation was that APRIL targets reactive astrocytes in this lesion of NMO similarly to MS.https://www.frontiersin.org/articles/10.3389/fneur.2021.721877/fullneuromyelitis opticaTACIastrocytesB cellsAPRIL (TNFSF13) |
| spellingShingle | Laurie Baert Romain Marignier Hans P. Lassmann Bertrand Huard Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica Frontiers in Neurology neuromyelitis optica TACI astrocytes B cells APRIL (TNFSF13) |
| title | Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica |
| title_full | Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica |
| title_fullStr | Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica |
| title_full_unstemmed | Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica |
| title_short | Case Report: In Situ Expression of a Proliferation-Inducing Ligand in Neuromyelitis Optica |
| title_sort | case report in situ expression of a proliferation inducing ligand in neuromyelitis optica |
| topic | neuromyelitis optica TACI astrocytes B cells APRIL (TNFSF13) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.721877/full |
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