Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems
The GATA family of transcription factors consists of six proteins (GATA1-6) that control a variety of physiological and pathological processes. In particular, GATA2 and GATA3 are coexpressed in a number of tissues, including in the urogenital and sympathoadrenal systems, in which both factors partic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/3/299 |
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| author | Takashi Moriguchi |
| author_facet | Takashi Moriguchi |
| author_sort | Takashi Moriguchi |
| collection | DOAJ |
| description | The GATA family of transcription factors consists of six proteins (GATA1-6) that control a variety of physiological and pathological processes. In particular, GATA2 and GATA3 are coexpressed in a number of tissues, including in the urogenital and sympathoadrenal systems, in which both factors participate in the developmental process and tissue maintenance. Furthermore, accumulating studies have demonstrated that GATA2 and GATA3 are involved in distinct types of inherited diseases as well as carcinogenesis in diverse tissues. This review summarizes our current knowledge of how GATA2 and GATA3 participate in the transcriptional regulatory circuitry during the development of the sympathoadrenal and urogenital systems, and how their dysregulation results in the carcinogenesis of neuroblastoma, renal urothelial, and gynecologic cancers. |
| first_indexed | 2024-03-10T13:15:02Z |
| format | Article |
| id | doaj.art-f4e7ec07c8864bc090ec40e9514d73cd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T13:15:02Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f4e7ec07c8864bc090ec40e9514d73cd2023-11-21T10:29:55ZengMDPI AGBiomedicines2227-90592021-03-019329910.3390/biomedicines9030299Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital SystemsTakashi Moriguchi0Division of Medical Biochemistry, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, JapanThe GATA family of transcription factors consists of six proteins (GATA1-6) that control a variety of physiological and pathological processes. In particular, GATA2 and GATA3 are coexpressed in a number of tissues, including in the urogenital and sympathoadrenal systems, in which both factors participate in the developmental process and tissue maintenance. Furthermore, accumulating studies have demonstrated that GATA2 and GATA3 are involved in distinct types of inherited diseases as well as carcinogenesis in diverse tissues. This review summarizes our current knowledge of how GATA2 and GATA3 participate in the transcriptional regulatory circuitry during the development of the sympathoadrenal and urogenital systems, and how their dysregulation results in the carcinogenesis of neuroblastoma, renal urothelial, and gynecologic cancers.https://www.mdpi.com/2227-9059/9/3/299GATA2GATA3sympathoadrenalurogenitalneuroblastomaurothelial cancer |
| spellingShingle | Takashi Moriguchi Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems Biomedicines GATA2 GATA3 sympathoadrenal urogenital neuroblastoma urothelial cancer |
| title | Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems |
| title_full | Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems |
| title_fullStr | Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems |
| title_full_unstemmed | Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems |
| title_short | Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems |
| title_sort | development and carcinogenesis roles of gata factors in the sympathoadrenal and urogenital systems |
| topic | GATA2 GATA3 sympathoadrenal urogenital neuroblastoma urothelial cancer |
| url | https://www.mdpi.com/2227-9059/9/3/299 |
| work_keys_str_mv | AT takashimoriguchi developmentandcarcinogenesisrolesofgatafactorsinthesympathoadrenalandurogenitalsystems |