Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis

The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute mye...

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Main Authors: Zühre Kaya, Nurettin Alıcı, Serap Kırkız, Ülker Koçak
Format: Article
Language:English
Published: Galenos Publishing House 2023-08-01
Series:Turkish Journal of Hematology
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-73444
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author Zühre Kaya
Nurettin Alıcı
Serap Kırkız
Ülker Koçak
author_facet Zühre Kaya
Nurettin Alıcı
Serap Kırkız
Ülker Koçak
author_sort Zühre Kaya
collection DOAJ
description The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.
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spelling doaj.art-f4e894ff81c04597b67c48e64b49cf352023-09-01T08:46:20ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632023-08-0140318318610.4274/tjh.galenos.2023.2023-0116TJH-73444Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin ProphylaxisZühre Kaya0Nurettin Alıcı1Serap Kırkız2Ülker Koçak3Gazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, TürkiyeGazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, TürkiyeGazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, TürkiyeGazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, TürkiyeThe purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-73444febrile neutropeniachildrenleukemiarisk factorprophylaxis
spellingShingle Zühre Kaya
Nurettin Alıcı
Serap Kırkız
Ülker Koçak
Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
Turkish Journal of Hematology
febrile neutropenia
children
leukemia
risk factor
prophylaxis
title Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
title_full Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
title_fullStr Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
title_full_unstemmed Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
title_short Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis
title_sort identifying risk factors and improving preventive strategies for febrile neutropenia in children with leukemia receiving ciprofloxacin prophylaxis
topic febrile neutropenia
children
leukemia
risk factor
prophylaxis
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-73444
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AT serapkırkız identifyingriskfactorsandimprovingpreventivestrategiesforfebrileneutropeniainchildrenwithleukemiareceivingciprofloxacinprophylaxis
AT ulkerkocak identifyingriskfactorsandimprovingpreventivestrategiesforfebrileneutropeniainchildrenwithleukemiareceivingciprofloxacinprophylaxis