Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering
Neuroprostheses are neuroengineering devices that have an interface with the nervous system and supplement or substitute functionality in people with disabilities. In the collective imagination, neuroprostheses are mostly used to restore sensory or motor capabilities, but in recent years, new device...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/11/1578 |
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| author | Michela Chiappalone Vinicius R. Cota Marta Carè Mattia Di Florio Romain Beaubois Stefano Buccelli Federico Barban Martina Brofiga Alberto Averna Francesco Bonacini David J. Guggenmos Yannick Bornat Paolo Massobrio Paolo Bonifazi Timothée Levi |
| author_facet | Michela Chiappalone Vinicius R. Cota Marta Carè Mattia Di Florio Romain Beaubois Stefano Buccelli Federico Barban Martina Brofiga Alberto Averna Francesco Bonacini David J. Guggenmos Yannick Bornat Paolo Massobrio Paolo Bonifazi Timothée Levi |
| author_sort | Michela Chiappalone |
| collection | DOAJ |
| description | Neuroprostheses are neuroengineering devices that have an interface with the nervous system and supplement or substitute functionality in people with disabilities. In the collective imagination, neuroprostheses are mostly used to restore sensory or motor capabilities, but in recent years, new devices directly acting at the brain level have been proposed. In order to design the next-generation of neuroprosthetic devices for brain repair, we foresee the increasing exploitation of closed-loop systems enabled with neuromorphic elements due to their intrinsic energy efficiency, their capability to perform real-time data processing, and of mimicking neurobiological computation for an improved synergy between the technological and biological counterparts. In this manuscript, after providing definitions of key concepts, we reviewed the first exploitation of a real-time hardware neuromorphic prosthesis to restore the bidirectional communication between two neuronal populations in vitro. Starting from that ‘case-study’, we provide perspectives on the technological improvements for real-time interfacing and processing of neural signals and their potential usage for novel in vitro and in vivo experimental designs. The development of innovative neuroprosthetics for translational purposes is also presented and discussed. In our understanding, the pursuit of neuromorphic-based closed-loop neuroprostheses may spur the development of novel powerful technologies, such as ‘brain-prostheses’, capable of rewiring and/or substituting the injured nervous system. |
| first_indexed | 2024-03-09T18:26:55Z |
| format | Article |
| id | doaj.art-f4ea3082818d4b3982710b93360553d1 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T18:26:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f4ea3082818d4b3982710b93360553d12023-11-24T07:50:08ZengMDPI AGBrain Sciences2076-34252022-11-011211157810.3390/brainsci12111578Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in NeuroengineeringMichela Chiappalone0Vinicius R. Cota1Marta Carè2Mattia Di Florio3Romain Beaubois4Stefano Buccelli5Federico Barban6Martina Brofiga7Alberto Averna8Francesco Bonacini9David J. Guggenmos10Yannick Bornat11Paolo Massobrio12Paolo Bonifazi13Timothée Levi14Department of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyRehab Technologies, Istituto Italiano di Tecnologia, 16163 Genova, ItalyDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyIMS Laboratory, CNRS UMR 5218, University of Bordeaux, 33405 Talence, FranceRehab Technologies, Istituto Italiano di Tecnologia, 16163 Genova, ItalyDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyDepartment of Neurology, Bern University Hospital, University of Bern, 3012 Bern, SwitzerlandDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyDepartment of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS 66103, USAIMS Laboratory, CNRS UMR 5218, University of Bordeaux, 33405 Talence, FranceDepartment of Informatics, Bioengineering, Robotics System Engineering (DIBRIS), University of Genova, 16145 Genova, ItalyIKERBASQUE, The Basque Fundation, 48009 Bilbao, SpainIMS Laboratory, CNRS UMR 5218, University of Bordeaux, 33405 Talence, FranceNeuroprostheses are neuroengineering devices that have an interface with the nervous system and supplement or substitute functionality in people with disabilities. In the collective imagination, neuroprostheses are mostly used to restore sensory or motor capabilities, but in recent years, new devices directly acting at the brain level have been proposed. In order to design the next-generation of neuroprosthetic devices for brain repair, we foresee the increasing exploitation of closed-loop systems enabled with neuromorphic elements due to their intrinsic energy efficiency, their capability to perform real-time data processing, and of mimicking neurobiological computation for an improved synergy between the technological and biological counterparts. In this manuscript, after providing definitions of key concepts, we reviewed the first exploitation of a real-time hardware neuromorphic prosthesis to restore the bidirectional communication between two neuronal populations in vitro. Starting from that ‘case-study’, we provide perspectives on the technological improvements for real-time interfacing and processing of neural signals and their potential usage for novel in vitro and in vivo experimental designs. The development of innovative neuroprosthetics for translational purposes is also presented and discussed. In our understanding, the pursuit of neuromorphic-based closed-loop neuroprostheses may spur the development of novel powerful technologies, such as ‘brain-prostheses’, capable of rewiring and/or substituting the injured nervous system.https://www.mdpi.com/2076-3425/12/11/1578closed-loopelectroceuticalsin vitroin vivoneuromorphicreal-time |
| spellingShingle | Michela Chiappalone Vinicius R. Cota Marta Carè Mattia Di Florio Romain Beaubois Stefano Buccelli Federico Barban Martina Brofiga Alberto Averna Francesco Bonacini David J. Guggenmos Yannick Bornat Paolo Massobrio Paolo Bonifazi Timothée Levi Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering Brain Sciences closed-loop electroceuticals in vitro in vivo neuromorphic real-time |
| title | Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering |
| title_full | Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering |
| title_fullStr | Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering |
| title_full_unstemmed | Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering |
| title_short | Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering |
| title_sort | neuromorphic based neuroprostheses for brain rewiring state of the art and perspectives in neuroengineering |
| topic | closed-loop electroceuticals in vitro in vivo neuromorphic real-time |
| url | https://www.mdpi.com/2076-3425/12/11/1578 |
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