Investigating the effects of the aging brain on real tool use performance—an fMRI study
IntroductionHealthy aging affects several domains of cognitive and motor performance and is further associated with multiple structural and functional neural reorganization patterns. However, gap of knowledge exists, referring to the impact of these age-related alterations on the neural basis of too...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1238731/full |
| _version_ | 1797739584711294976 |
|---|---|
| author | Clara Seifert Jingkang Zhao Jingkang Zhao Marie-Luise Brandi Marie-Luise Brandi Thabea Kampe Joachim Hermsdörfer Afra Wohlschläger Afra Wohlschläger |
| author_facet | Clara Seifert Jingkang Zhao Jingkang Zhao Marie-Luise Brandi Marie-Luise Brandi Thabea Kampe Joachim Hermsdörfer Afra Wohlschläger Afra Wohlschläger |
| author_sort | Clara Seifert |
| collection | DOAJ |
| description | IntroductionHealthy aging affects several domains of cognitive and motor performance and is further associated with multiple structural and functional neural reorganization patterns. However, gap of knowledge exists, referring to the impact of these age-related alterations on the neural basis of tool use–an important, complex action involved in everyday life throughout the entire lifespan. The current fMRI study aims to investigate age-related changes of neural correlates involved in planning and executing a complex object manipulation task, further providing a better understanding of impaired tool use performance in apraxia patients.MethodsA balanced number of sixteen older and younger healthy adults repeatedly manipulated everyday tools in an event-related Go-No-Go fMRI paradigm.ResultsOur data indicates that the left-lateralized network, including widely distributed frontal, temporal, parietal and occipital regions, involved in tool use performance is not subjected to age-related functional reorganization processes. However, age-related changes regarding the applied strategical procedure can be detected, indicating stronger investment into the planning, preparatory phase of such an action in older participants. |
| first_indexed | 2024-03-12T13:59:18Z |
| format | Article |
| id | doaj.art-f4ea54ca531344cc94114e83478ad239 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T13:59:18Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f4ea54ca531344cc94114e83478ad2392023-08-22T09:26:12ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-08-011510.3389/fnagi.2023.12387311238731Investigating the effects of the aging brain on real tool use performance—an fMRI studyClara Seifert0Jingkang Zhao1Jingkang Zhao2Marie-Luise Brandi3Marie-Luise Brandi4Thabea Kampe5Joachim Hermsdörfer6Afra Wohlschläger7Afra Wohlschläger8Chair of Human Movement Science, Department of Sport and Health Sciences, Technical University of Munich, Munich, GermanyDepartment of Electrical and Computer Engineering, Technical University of Munich, Munich, GermanyDepartment of Neuroradiology, TUM-Neuroimaging Center, Technical University of Munich, Munich, GermanyDepartment of Neuroradiology, TUM-Neuroimaging Center, Technical University of Munich, Munich, GermanyGraduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Munich, GermanyChair of Human Movement Science, Department of Sport and Health Sciences, Technical University of Munich, Munich, GermanyChair of Human Movement Science, Department of Sport and Health Sciences, Technical University of Munich, Munich, GermanyDepartment of Neuroradiology, TUM-Neuroimaging Center, Technical University of Munich, Munich, GermanyGraduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Munich, GermanyIntroductionHealthy aging affects several domains of cognitive and motor performance and is further associated with multiple structural and functional neural reorganization patterns. However, gap of knowledge exists, referring to the impact of these age-related alterations on the neural basis of tool use–an important, complex action involved in everyday life throughout the entire lifespan. The current fMRI study aims to investigate age-related changes of neural correlates involved in planning and executing a complex object manipulation task, further providing a better understanding of impaired tool use performance in apraxia patients.MethodsA balanced number of sixteen older and younger healthy adults repeatedly manipulated everyday tools in an event-related Go-No-Go fMRI paradigm.ResultsOur data indicates that the left-lateralized network, including widely distributed frontal, temporal, parietal and occipital regions, involved in tool use performance is not subjected to age-related functional reorganization processes. However, age-related changes regarding the applied strategical procedure can be detected, indicating stronger investment into the planning, preparatory phase of such an action in older participants.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1238731/fulltool usebrain representationapraxiahealthy agingfMRI |
| spellingShingle | Clara Seifert Jingkang Zhao Jingkang Zhao Marie-Luise Brandi Marie-Luise Brandi Thabea Kampe Joachim Hermsdörfer Afra Wohlschläger Afra Wohlschläger Investigating the effects of the aging brain on real tool use performance—an fMRI study Frontiers in Aging Neuroscience tool use brain representation apraxia healthy aging fMRI |
| title | Investigating the effects of the aging brain on real tool use performance—an fMRI study |
| title_full | Investigating the effects of the aging brain on real tool use performance—an fMRI study |
| title_fullStr | Investigating the effects of the aging brain on real tool use performance—an fMRI study |
| title_full_unstemmed | Investigating the effects of the aging brain on real tool use performance—an fMRI study |
| title_short | Investigating the effects of the aging brain on real tool use performance—an fMRI study |
| title_sort | investigating the effects of the aging brain on real tool use performance an fmri study |
| topic | tool use brain representation apraxia healthy aging fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1238731/full |
| work_keys_str_mv | AT claraseifert investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT jingkangzhao investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT jingkangzhao investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT marieluisebrandi investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT marieluisebrandi investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT thabeakampe investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT joachimhermsdorfer investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT afrawohlschlager investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy AT afrawohlschlager investigatingtheeffectsoftheagingbrainonrealtooluseperformanceanfmristudy |