Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study
Abstract Background Oncologic impact of genetic alteration across synchronous colorectal cancer (CRC) still remains unclear. This study aimed to compare the oncologic relevance according to genetic alteration between synchronous and solitary CRC with performing systematic review. Methods Multicenter...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02937-7 |
| _version_ | 1797452483483664384 |
|---|---|
| author | Il Tae Son Minsung Kim Bo Young Oh Min Jeong Kim Sang Nam Yoon Jun Ho Park Byung Chun Kim Jong Wan Kim |
| author_facet | Il Tae Son Minsung Kim Bo Young Oh Min Jeong Kim Sang Nam Yoon Jun Ho Park Byung Chun Kim Jong Wan Kim |
| author_sort | Il Tae Son |
| collection | DOAJ |
| description | Abstract Background Oncologic impact of genetic alteration across synchronous colorectal cancer (CRC) still remains unclear. This study aimed to compare the oncologic relevance according to genetic alteration between synchronous and solitary CRC with performing systematic review. Methods Multicenter retrospective analysis was performed for CRC patients with curative resection. Genetic profiling was consisted of microsatellite instability (MSI) testing, RAS (K-ras, and N-ras), and BRAF (v-Raf murine sarcoma viral oncogene homolog B1) V600E mutation. Multivariate analyses were conducted using logistic regression for synchronicity, and Cox proportional hazard model with stage-adjusting for overall survival (OS) and disease-free survival (DFS). Results It was identified synchronous (n = 36) and solitary (n = 579) CRC with similar base line characteristics. RAS mutation was associated to synchronous CRC with no relations of MSI and BRAF. During median follow up of 77.8 month, Kaplan–meier curves showed significant differences according to MSI-high for OS, and in RAS, and BRAF mutation for DFS, respectively. In multivariable analyses, RAS and BRAF mutation were independent factors (RAS, HR = 1.808, 95% CI = 1.18–2.77, p = 0.007; BRAF, HR = 2.417, 95% CI = 1.32–4.41, p = 0.004). Old age was independent factor for OS (HR = 3.626, 95% CI = 1.09–12.00, p = 0.035). Conclusion This study showed that oncologic outcomes might differ according to mutation burden characterized by RAS, BRAF, and MSI between synchronous CRC and solitary CRC. In addition, our systematic review highlighted a lack of data and much heterogeneity in genetic characteristics and survival outcomes of synchronous CRC relative to that of solitary CRC. |
| first_indexed | 2024-03-09T15:09:21Z |
| format | Article |
| id | doaj.art-f4ebb257e950411c832bf184cbc29e27 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-09T15:09:21Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-f4ebb257e950411c832bf184cbc29e272023-11-26T13:30:00ZengBMCBMC Gastroenterology1471-230X2023-09-0123111710.1186/s12876-023-02937-7Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter studyIl Tae Son0Minsung Kim1Bo Young Oh2Min Jeong Kim3Sang Nam Yoon4Jun Ho Park5Byung Chun Kim6Jong Wan Kim7Department of Surgery, Hallym Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Hallym Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Hallym Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of MedicineDepartment of Surgery, Dongtan Sacred Heart Hospital, Hallym University College of MedicineAbstract Background Oncologic impact of genetic alteration across synchronous colorectal cancer (CRC) still remains unclear. This study aimed to compare the oncologic relevance according to genetic alteration between synchronous and solitary CRC with performing systematic review. Methods Multicenter retrospective analysis was performed for CRC patients with curative resection. Genetic profiling was consisted of microsatellite instability (MSI) testing, RAS (K-ras, and N-ras), and BRAF (v-Raf murine sarcoma viral oncogene homolog B1) V600E mutation. Multivariate analyses were conducted using logistic regression for synchronicity, and Cox proportional hazard model with stage-adjusting for overall survival (OS) and disease-free survival (DFS). Results It was identified synchronous (n = 36) and solitary (n = 579) CRC with similar base line characteristics. RAS mutation was associated to synchronous CRC with no relations of MSI and BRAF. During median follow up of 77.8 month, Kaplan–meier curves showed significant differences according to MSI-high for OS, and in RAS, and BRAF mutation for DFS, respectively. In multivariable analyses, RAS and BRAF mutation were independent factors (RAS, HR = 1.808, 95% CI = 1.18–2.77, p = 0.007; BRAF, HR = 2.417, 95% CI = 1.32–4.41, p = 0.004). Old age was independent factor for OS (HR = 3.626, 95% CI = 1.09–12.00, p = 0.035). Conclusion This study showed that oncologic outcomes might differ according to mutation burden characterized by RAS, BRAF, and MSI between synchronous CRC and solitary CRC. In addition, our systematic review highlighted a lack of data and much heterogeneity in genetic characteristics and survival outcomes of synchronous CRC relative to that of solitary CRC.https://doi.org/10.1186/s12876-023-02937-7Synchronous colorectal cancerGene mutationSurvival |
| spellingShingle | Il Tae Son Minsung Kim Bo Young Oh Min Jeong Kim Sang Nam Yoon Jun Ho Park Byung Chun Kim Jong Wan Kim Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study BMC Gastroenterology Synchronous colorectal cancer Gene mutation Survival |
| title | Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study |
| title_full | Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study |
| title_fullStr | Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study |
| title_full_unstemmed | Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study |
| title_short | Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study |
| title_sort | oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer a retrospective multicenter study |
| topic | Synchronous colorectal cancer Gene mutation Survival |
| url | https://doi.org/10.1186/s12876-023-02937-7 |
| work_keys_str_mv | AT iltaeson oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT minsungkim oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT boyoungoh oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT minjeongkim oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT sangnamyoon oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT junhopark oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT byungchunkim oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy AT jongwankim oncologicrelevanceofgeneticalterationsinsporadicsynchronousandsolitarycolorectalcanceraretrospectivemulticenterstudy |