Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma
Non-coding RNAs (ncRNAs) comprise a diversity of RNA species, which do not have the potential to encode proteins. Non-coding RNAs include two classes of RNAs, namely: short regulatory ncRNAs and long non-coding RNAs (lncRNAs). The short regulatory RNAs, containing up to 200 nucleotides, include smal...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2611 |
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| author | Carlos DeOcesano-Pereira Raquel A. C. Machado Ana Marisa Chudzinski-Tavassi Mari Cleide Sogayar |
| author_facet | Carlos DeOcesano-Pereira Raquel A. C. Machado Ana Marisa Chudzinski-Tavassi Mari Cleide Sogayar |
| author_sort | Carlos DeOcesano-Pereira |
| collection | DOAJ |
| description | Non-coding RNAs (ncRNAs) comprise a diversity of RNA species, which do not have the potential to encode proteins. Non-coding RNAs include two classes of RNAs, namely: short regulatory ncRNAs and long non-coding RNAs (lncRNAs). The short regulatory RNAs, containing up to 200 nucleotides, include small RNAs, such as microRNAs (miRNA), short interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs). The lncRNAs include long antisense RNAs and long intergenic RNAs (lincRNAs). Non-coding RNAs have been implicated as master regulators of several biological processes, their expression being strictly regulated under physiological conditions. In recent years, particularly in the last decade, substantial effort has been made to investigate the function of ncRNAs in several human diseases, including cancer. Glioblastoma is the most common and aggressive type of brain cancer in adults, with deregulated expression of small and long ncRNAs having been implicated in onset, progression, invasiveness, and recurrence of this tumor. The aim of this review is to guide the reader through important aspects of miRNA and lncRNA biology, focusing on the molecular mechanism associated with the progression of this highly malignant cancer type. |
| first_indexed | 2024-03-10T20:34:59Z |
| format | Article |
| id | doaj.art-f4ec601f3c42428fac47c8cde8d0332d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:34:59Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4ec601f3c42428fac47c8cde8d0332d2023-11-19T21:07:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217261110.3390/ijms21072611Emerging Roles and Potential Applications of Non-Coding RNAs in GlioblastomaCarlos DeOcesano-Pereira0Raquel A. C. Machado1Ana Marisa Chudzinski-Tavassi2Mari Cleide Sogayar3Center of Excellence in New Target Discovery (CENTD), Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900 SP, BrazilDepartment of Life Science and Medicine, University of Luxembourg, Campus Belval, Avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, LuxembourgCenter of Excellence in New Target Discovery (CENTD), Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900 SP, BrazilBiochemistry Department, Chemistry Institute, University of São Paulo, São Paulo 05508-000, BrazilNon-coding RNAs (ncRNAs) comprise a diversity of RNA species, which do not have the potential to encode proteins. Non-coding RNAs include two classes of RNAs, namely: short regulatory ncRNAs and long non-coding RNAs (lncRNAs). The short regulatory RNAs, containing up to 200 nucleotides, include small RNAs, such as microRNAs (miRNA), short interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs). The lncRNAs include long antisense RNAs and long intergenic RNAs (lincRNAs). Non-coding RNAs have been implicated as master regulators of several biological processes, their expression being strictly regulated under physiological conditions. In recent years, particularly in the last decade, substantial effort has been made to investigate the function of ncRNAs in several human diseases, including cancer. Glioblastoma is the most common and aggressive type of brain cancer in adults, with deregulated expression of small and long ncRNAs having been implicated in onset, progression, invasiveness, and recurrence of this tumor. The aim of this review is to guide the reader through important aspects of miRNA and lncRNA biology, focusing on the molecular mechanism associated with the progression of this highly malignant cancer type.https://www.mdpi.com/1422-0067/21/7/2611glioblastomanon-coding RNAsmiRNAslncRNAsregulation of gene expression |
| spellingShingle | Carlos DeOcesano-Pereira Raquel A. C. Machado Ana Marisa Chudzinski-Tavassi Mari Cleide Sogayar Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma International Journal of Molecular Sciences glioblastoma non-coding RNAs miRNAs lncRNAs regulation of gene expression |
| title | Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma |
| title_full | Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma |
| title_fullStr | Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma |
| title_full_unstemmed | Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma |
| title_short | Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma |
| title_sort | emerging roles and potential applications of non coding rnas in glioblastoma |
| topic | glioblastoma non-coding RNAs miRNAs lncRNAs regulation of gene expression |
| url | https://www.mdpi.com/1422-0067/21/7/2611 |
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