Chemistry and bioactivity of nobiletin and its metabolites
The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613003058 |
| _version_ | 1819055310342455296 |
|---|---|
| author | Shiming Li Hong Wang Limin Guo Hui Zhao Chi-Tang Ho |
| author_facet | Shiming Li Hong Wang Limin Guo Hui Zhao Chi-Tang Ho |
| author_sort | Shiming Li |
| collection | DOAJ |
| description | The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity. Major nobiletin metabolites from rodent biofluids have been successfully characterized, isolated or synthesized for the evaluation of their biological activities and subsequently revealed that nobiletin metabolites demonstrate similar efficacies or more potent anti-oxidant activity and scavenging property against free radicals and in the inhibition of inflammation and cancer growth, and the prevention of metabolic syndrome and cardiovascular diseases. This review starts with basic chemistry of nobiletin and other polymethoxyflavones, highlights their biological properties and recent findings and summarizes nobiletin’s biotransformation and biological activities of the main nobiletin metabolites. |
| first_indexed | 2024-12-21T13:05:29Z |
| format | Article |
| id | doaj.art-f4ee2a6cbad34478b69c465557a9ed5c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T13:05:29Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f4ee2a6cbad34478b69c465557a9ed5c2022-12-21T19:03:03ZengElsevierJournal of Functional Foods1756-46462014-01-016210Chemistry and bioactivity of nobiletin and its metabolitesShiming Li0Hong Wang1Limin Guo2Hui Zhao3Chi-Tang Ho4Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Hubei, 438000, China; Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA; Corresponding authors. Address: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. Tel.: +1 973 919 3702.Shaklee Corporation, 4747 Willow Road, Pleasanton, CA 94588, USAXinjiang Academy of Agricultural Sciences, Urumqi, Xinjiang 830091, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, ChinaDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USA; Corresponding authors. Address: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. Tel.: +1 973 919 3702.The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity. Major nobiletin metabolites from rodent biofluids have been successfully characterized, isolated or synthesized for the evaluation of their biological activities and subsequently revealed that nobiletin metabolites demonstrate similar efficacies or more potent anti-oxidant activity and scavenging property against free radicals and in the inhibition of inflammation and cancer growth, and the prevention of metabolic syndrome and cardiovascular diseases. This review starts with basic chemistry of nobiletin and other polymethoxyflavones, highlights their biological properties and recent findings and summarizes nobiletin’s biotransformation and biological activities of the main nobiletin metabolites.http://www.sciencedirect.com/science/article/pii/S1756464613003058NobiletinMetaboliteBioactivityPolymethoxyflavone |
| spellingShingle | Shiming Li Hong Wang Limin Guo Hui Zhao Chi-Tang Ho Chemistry and bioactivity of nobiletin and its metabolites Journal of Functional Foods Nobiletin Metabolite Bioactivity Polymethoxyflavone |
| title | Chemistry and bioactivity of nobiletin and its metabolites |
| title_full | Chemistry and bioactivity of nobiletin and its metabolites |
| title_fullStr | Chemistry and bioactivity of nobiletin and its metabolites |
| title_full_unstemmed | Chemistry and bioactivity of nobiletin and its metabolites |
| title_short | Chemistry and bioactivity of nobiletin and its metabolites |
| title_sort | chemistry and bioactivity of nobiletin and its metabolites |
| topic | Nobiletin Metabolite Bioactivity Polymethoxyflavone |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613003058 |
| work_keys_str_mv | AT shimingli chemistryandbioactivityofnobiletinanditsmetabolites AT hongwang chemistryandbioactivityofnobiletinanditsmetabolites AT liminguo chemistryandbioactivityofnobiletinanditsmetabolites AT huizhao chemistryandbioactivityofnobiletinanditsmetabolites AT chitangho chemistryandbioactivityofnobiletinanditsmetabolites |