Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke
Abstract Background Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that are positively associated with body in...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00733-9 |
| _version_ | 1817976520960901120 |
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| author | Kai-bin Lin Feng-hua Fan Ming-qi Cai Yin Yu Chuan-liang Fu Lu-yue Ding Yu-dong Sun Jia-wen Sun Yong-wang Shi Zhi-feng Dong Min-Jie Yuan Shuai Li Yan-peng Wang Kan-kai Chen Ji-ni Zhu Xin-wei Guo Xue Zhang Yu-wu Zhao Jing-bo Li Dong Huang |
| author_facet | Kai-bin Lin Feng-hua Fan Ming-qi Cai Yin Yu Chuan-liang Fu Lu-yue Ding Yu-dong Sun Jia-wen Sun Yong-wang Shi Zhi-feng Dong Min-Jie Yuan Shuai Li Yan-peng Wang Kan-kai Chen Ji-ni Zhu Xin-wei Guo Xue Zhang Yu-wu Zhao Jing-bo Li Dong Huang |
| author_sort | Kai-bin Lin |
| collection | DOAJ |
| description | Abstract Background Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that are positively associated with body inflammation. However, little is known regarding the association between SIII/SIRI with the presence of AF among the patients with ischemic stroke. Methods A total of 526 ischemic stroke patients (173 with AF and 353 without AF) were consecutively enrolled in our study from January 2017 to June 2019. SIII and SIRI were measured in both groups. Logistic regression analysis was used to analyse the potential association between SIII/SIRI and the presence of AF. Finally, the correlation between hospitalization expenses, changes in the National Institutes of Health Stroke Scale (NIHSS) scores and SIII/SIRI values were measured. Results In patients with ischemic stroke, SIII and SIRI values were significantly higher in AF patients than in non-AF patients (all p < 0.001). Moreover, with increasing quartiles of SIII and SIRI in all patients, the proportion of patients with AF was higher than that of non-AF patients gradually. Logistic regression analyses demonstrated that log-transformed SIII and log-transformed SIRI were independently associated with the presence of AF in patients with ischemic stroke (log-transformed SIII: odds ratio [OR]: 1.047, 95% confidence interval CI = 0.322–1.105, p = 0.047; log-transformed SIRI: OR: 6.197, 95% CI = 2.196–17.484, p = 0.001). Finally, a positive correlation between hospitalization expenses, changes in the NIHSS scores and SIII/SIRI were found, which were more significant in patients with AF (all p < 0.05). Conclusions Our study suggests SIII and SIRI are convenient and effective measurements for predicting the presence of AF in patients with ischemic stroke. Moreover, they were correlated with increased financial burden and poor short-term prognosis in AF patients presenting with ischemic stroke. |
| first_indexed | 2024-04-13T22:04:41Z |
| format | Article |
| id | doaj.art-f4ee73a16bed49f69d926aaae065327e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-13T22:04:41Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f4ee73a16bed49f69d926aaae065327e2022-12-22T02:27:59ZengBMCEuropean Journal of Medical Research2047-783X2022-07-012711810.1186/s40001-022-00733-9Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic strokeKai-bin Lin0Feng-hua Fan1Ming-qi Cai2Yin Yu3Chuan-liang Fu4Lu-yue Ding5Yu-dong Sun6Jia-wen Sun7Yong-wang Shi8Zhi-feng Dong9Min-Jie Yuan10Shuai Li11Yan-peng Wang12Kan-kai Chen13Ji-ni Zhu14Xin-wei Guo15Xue Zhang16Yu-wu Zhao17Jing-bo Li18Dong Huang19Heart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictSchool of Medicine, Shanghai Jiaotong UniversitySchool of Medicine, Shanghai Jiaotong UniversitySchool of Medicine, Shanghai Jiaotong UniversitySchool of Biomedical Engineering, Shanghai Jiao Tong UniversityZhiyuan College, Shanghai Jiaotong UniversityHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictDepartment of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong UniversityHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictHeart Center, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Xuhui DistrictAbstract Background Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that are positively associated with body inflammation. However, little is known regarding the association between SIII/SIRI with the presence of AF among the patients with ischemic stroke. Methods A total of 526 ischemic stroke patients (173 with AF and 353 without AF) were consecutively enrolled in our study from January 2017 to June 2019. SIII and SIRI were measured in both groups. Logistic regression analysis was used to analyse the potential association between SIII/SIRI and the presence of AF. Finally, the correlation between hospitalization expenses, changes in the National Institutes of Health Stroke Scale (NIHSS) scores and SIII/SIRI values were measured. Results In patients with ischemic stroke, SIII and SIRI values were significantly higher in AF patients than in non-AF patients (all p < 0.001). Moreover, with increasing quartiles of SIII and SIRI in all patients, the proportion of patients with AF was higher than that of non-AF patients gradually. Logistic regression analyses demonstrated that log-transformed SIII and log-transformed SIRI were independently associated with the presence of AF in patients with ischemic stroke (log-transformed SIII: odds ratio [OR]: 1.047, 95% confidence interval CI = 0.322–1.105, p = 0.047; log-transformed SIRI: OR: 6.197, 95% CI = 2.196–17.484, p = 0.001). Finally, a positive correlation between hospitalization expenses, changes in the NIHSS scores and SIII/SIRI were found, which were more significant in patients with AF (all p < 0.05). Conclusions Our study suggests SIII and SIRI are convenient and effective measurements for predicting the presence of AF in patients with ischemic stroke. Moreover, they were correlated with increased financial burden and poor short-term prognosis in AF patients presenting with ischemic stroke.https://doi.org/10.1186/s40001-022-00733-9Atrial fibrillationSystemic immune inflammation indexSystemic inflammation response indexIschemic stroke |
| spellingShingle | Kai-bin Lin Feng-hua Fan Ming-qi Cai Yin Yu Chuan-liang Fu Lu-yue Ding Yu-dong Sun Jia-wen Sun Yong-wang Shi Zhi-feng Dong Min-Jie Yuan Shuai Li Yan-peng Wang Kan-kai Chen Ji-ni Zhu Xin-wei Guo Xue Zhang Yu-wu Zhao Jing-bo Li Dong Huang Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke European Journal of Medical Research Atrial fibrillation Systemic immune inflammation index Systemic inflammation response index Ischemic stroke |
| title | Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| title_full | Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| title_fullStr | Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| title_full_unstemmed | Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| title_short | Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| title_sort | systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke |
| topic | Atrial fibrillation Systemic immune inflammation index Systemic inflammation response index Ischemic stroke |
| url | https://doi.org/10.1186/s40001-022-00733-9 |
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