Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients
<i>Background and Objectives</i>: Direct-acting antiviral agents (DAAs) have improved sustained virologic response (SVR) rates in patients with chronic hepatitis C virus (HCV) infection. Our aim was to elucidate the occurrence of hepatocellular carcinoma (HCC) and to compare the outcomes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/761 |
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| author | Kazushige Nirei Tatsuo Kanda Ryota Masuzaki Taku Mizutani Mitsuhiko Moriyama |
| author_facet | Kazushige Nirei Tatsuo Kanda Ryota Masuzaki Taku Mizutani Mitsuhiko Moriyama |
| author_sort | Kazushige Nirei |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Direct-acting antiviral agents (DAAs) have improved sustained virologic response (SVR) rates in patients with chronic hepatitis C virus (HCV) infection. Our aim was to elucidate the occurrence of hepatocellular carcinoma (HCC) and to compare the outcomes of patients aged 75 years or older (older group) with those of patients younger than 75 years (younger group) after SVR. <i>Materials and Methods</i>: Among 441 patients treated with interferon-free DAA combinations, a total of 409 SVR patients were analyzed. We compared the two age groups in terms of HCC incidence and mortality rates. <i>Results</i>: Older and younger groups consisted of 68 and 341 patients, respectively. Occurrence of HCC after SVR did not differ between the two groups of patients with a history of HCC. Occurrence of HCC after SVR was observed more in younger patients without a history of HCC (<i>p</i> < 0.01). Although older patients without a history of HCC had a higher mortality rate (<i>p</i> < 0.01), their causes of death were not associated with liver diseases. Among younger patients without a history of HCC, none died. <i>Conclusions</i>: After SVR, liver disease may not be a prognostic factor in older HCV patients without a history of HCC. |
| first_indexed | 2024-03-10T08:37:39Z |
| format | Article |
| id | doaj.art-f4efa3634092418fb8512ac3fd181b16 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:37:39Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-f4efa3634092418fb8512ac3fd181b162023-11-22T08:35:43ZengMDPI AGMedicina1010-660X1648-91442021-07-0157876110.3390/medicina57080761Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older PatientsKazushige Nirei0Tatsuo Kanda1Ryota Masuzaki2Taku Mizutani3Mitsuhiko Moriyama4Department of Medicine, Division of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, JapanDepartment of Medicine, Division of Gastroenterology and Hepatology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan<i>Background and Objectives</i>: Direct-acting antiviral agents (DAAs) have improved sustained virologic response (SVR) rates in patients with chronic hepatitis C virus (HCV) infection. Our aim was to elucidate the occurrence of hepatocellular carcinoma (HCC) and to compare the outcomes of patients aged 75 years or older (older group) with those of patients younger than 75 years (younger group) after SVR. <i>Materials and Methods</i>: Among 441 patients treated with interferon-free DAA combinations, a total of 409 SVR patients were analyzed. We compared the two age groups in terms of HCC incidence and mortality rates. <i>Results</i>: Older and younger groups consisted of 68 and 341 patients, respectively. Occurrence of HCC after SVR did not differ between the two groups of patients with a history of HCC. Occurrence of HCC after SVR was observed more in younger patients without a history of HCC (<i>p</i> < 0.01). Although older patients without a history of HCC had a higher mortality rate (<i>p</i> < 0.01), their causes of death were not associated with liver diseases. Among younger patients without a history of HCC, none died. <i>Conclusions</i>: After SVR, liver disease may not be a prognostic factor in older HCV patients without a history of HCC.https://www.mdpi.com/1648-9144/57/8/76175 years or olderdirect-acting antiviral agenthepatitis C virusprognostic factors |
| spellingShingle | Kazushige Nirei Tatsuo Kanda Ryota Masuzaki Taku Mizutani Mitsuhiko Moriyama Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients Medicina 75 years or older direct-acting antiviral agent hepatitis C virus prognostic factors |
| title | Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients |
| title_full | Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients |
| title_fullStr | Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients |
| title_full_unstemmed | Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients |
| title_short | Follow-Up of Patients Who Achieved Sustained Virologic Response after Interferon-Free Treatment against Hepatitis C Virus: Focus on Older Patients |
| title_sort | follow up of patients who achieved sustained virologic response after interferon free treatment against hepatitis c virus focus on older patients |
| topic | 75 years or older direct-acting antiviral agent hepatitis C virus prognostic factors |
| url | https://www.mdpi.com/1648-9144/57/8/761 |
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