Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

Background Erlotinib (ERL) and Gefitinib (GEF) are considered first line therapy for the management of non-small cell lung carcinoma (NSCLC). Like other tyrosine kinase inhibitors (TKIs), ERL and GEF are mainly metabolized by the cytochrome P450 (CYP450) CYP3A4 isoform and are substrates for transpo...

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Bibliographic Details
Main Authors: Aliyah Almomen, Hadir M. Maher, Nourah Z. Alzoman, Shereen M. Shehata, Amal Alsubaie
Format: Article
Language:English
Published: PeerJ Inc. 2020-09-01
Series:PeerJ
Subjects:
Flavored water
Tyrosin Kinase Inhibitors
Erlotinib
Gefitinib
Pharmacokinetic
Rat
Online Access:https://peerj.com/articles/9881.pdf

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