Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying
Electrospinning technology was used to produced polyvinylpyrrolidone (PVP)-copper salt composites with structural differences, and their virucidal activity against coronavirus was investigated. The solutions were prepared with 20, 13.3, 10, and 6.6% <i>w</i>/<i>v</i> PVP cont...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/19/4157 |
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| author | João de Deus Pereira de Moraes Segundo Jamilly Salustiano Ferreira Constantino Guilherme Bedeschi Calais Celso Fidelis de Moura Junior Maria Oneide Silva de Moraes Jéssica Heline Lopes da Fonseca Junko Tsukamoto Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Marcos Akira d’Ávila Clarice Weis Arns Marisa Masumi Beppu Rodrigo Silveira Vieira |
| author_facet | João de Deus Pereira de Moraes Segundo Jamilly Salustiano Ferreira Constantino Guilherme Bedeschi Calais Celso Fidelis de Moura Junior Maria Oneide Silva de Moraes Jéssica Heline Lopes da Fonseca Junko Tsukamoto Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Marcos Akira d’Ávila Clarice Weis Arns Marisa Masumi Beppu Rodrigo Silveira Vieira |
| author_sort | João de Deus Pereira de Moraes Segundo |
| collection | DOAJ |
| description | Electrospinning technology was used to produced polyvinylpyrrolidone (PVP)-copper salt composites with structural differences, and their virucidal activity against coronavirus was investigated. The solutions were prepared with 20, 13.3, 10, and 6.6% <i>w</i>/<i>v</i> PVP containing 3, 1.0, 0.6, and 0.2% <i>w</i>/<i>v</i> Cu (II), respectively. The rheological properties and electrical conductivity contributing to the formation of the morphologies of the composite materials were observed by scanning electron microscopy (SEM). SEM images revealed the formation of electrospun PVP-copper salt ultrafine composite fibers (0.80 ± 0.35 µm) and electrosprayed PVP-copper salt composite microparticles (1.50 ± 0.70 µm). Energy-dispersive X-ray spectroscopy (EDS) evidenced the incorporation of copper into the produced composite materials. IR spectra confirmed the chemical composition and showed an interaction of Cu (II) ions with oxygen in the PVP resonant ring. Virucidal composite fibers inactivated 99.999% of coronavirus within 5 min of contact time, with moderate cytotoxicity to L929 cells, whereas the virucidal composite microparticles presented with a virucidal efficiency of 99.999% within 1440 min of exposure, with low cytotoxicity to L929 cells (mouse fibroblast). This produced virucidal composite materials have the potential to be applied in respirators, personal protective equipment, self-cleaning surfaces, and to fabric coat personal protective equipment against SARS-CoV-2, viral outbreaks, or pandemics. |
| first_indexed | 2024-03-09T21:15:28Z |
| format | Article |
| id | doaj.art-f4f0501243904f61b1660a7126e627e9 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T21:15:28Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-f4f0501243904f61b1660a7126e627e92023-11-23T21:35:16ZengMDPI AGPolymers2073-43602022-10-011419415710.3390/polym14194157Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and ElectrosprayingJoão de Deus Pereira de Moraes Segundo0Jamilly Salustiano Ferreira Constantino1Guilherme Bedeschi Calais2Celso Fidelis de Moura Junior3Maria Oneide Silva de Moraes4Jéssica Heline Lopes da Fonseca5Junko Tsukamoto6Rodolpho Ramilton de Castro Monteiro7Fábia Karine Andrade8Marcos Akira d’Ávila9Clarice Weis Arns10Marisa Masumi Beppu11Rodrigo Silveira Vieira12Department of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, BrazilDepartment of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, BrazilDepartment of Materials and Bioprocess Engineering, University of Campinas, Campinas 13083-852, BrazilDepartment of Materials and Bioprocess Engineering, University of Campinas, Campinas 13083-852, BrazilThematic Laboratory of Microscopy and Nanotechnology, National Institute of Amazonian Research, Manaus 69067-001, BrazilDepartment of Manufacturing and Materials Engineering, University of Campinas, Campinas 13083-860, BrazilDepartment of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas 13083-970, BrazilDepartment of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, BrazilDepartment of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, BrazilDepartment of Manufacturing and Materials Engineering, University of Campinas, Campinas 13083-860, BrazilDepartment of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas 13083-970, BrazilDepartment of Materials and Bioprocess Engineering, University of Campinas, Campinas 13083-852, BrazilDepartment of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, BrazilElectrospinning technology was used to produced polyvinylpyrrolidone (PVP)-copper salt composites with structural differences, and their virucidal activity against coronavirus was investigated. The solutions were prepared with 20, 13.3, 10, and 6.6% <i>w</i>/<i>v</i> PVP containing 3, 1.0, 0.6, and 0.2% <i>w</i>/<i>v</i> Cu (II), respectively. The rheological properties and electrical conductivity contributing to the formation of the morphologies of the composite materials were observed by scanning electron microscopy (SEM). SEM images revealed the formation of electrospun PVP-copper salt ultrafine composite fibers (0.80 ± 0.35 µm) and electrosprayed PVP-copper salt composite microparticles (1.50 ± 0.70 µm). Energy-dispersive X-ray spectroscopy (EDS) evidenced the incorporation of copper into the produced composite materials. IR spectra confirmed the chemical composition and showed an interaction of Cu (II) ions with oxygen in the PVP resonant ring. Virucidal composite fibers inactivated 99.999% of coronavirus within 5 min of contact time, with moderate cytotoxicity to L929 cells, whereas the virucidal composite microparticles presented with a virucidal efficiency of 99.999% within 1440 min of exposure, with low cytotoxicity to L929 cells (mouse fibroblast). This produced virucidal composite materials have the potential to be applied in respirators, personal protective equipment, self-cleaning surfaces, and to fabric coat personal protective equipment against SARS-CoV-2, viral outbreaks, or pandemics.https://www.mdpi.com/2073-4360/14/19/4157electrospinning technologypolyvinylpyrrolidonecoppercoronavirus |
| spellingShingle | João de Deus Pereira de Moraes Segundo Jamilly Salustiano Ferreira Constantino Guilherme Bedeschi Calais Celso Fidelis de Moura Junior Maria Oneide Silva de Moraes Jéssica Heline Lopes da Fonseca Junko Tsukamoto Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Marcos Akira d’Ávila Clarice Weis Arns Marisa Masumi Beppu Rodrigo Silveira Vieira Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying Polymers electrospinning technology polyvinylpyrrolidone copper coronavirus |
| title | Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying |
| title_full | Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying |
| title_fullStr | Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying |
| title_full_unstemmed | Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying |
| title_short | Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying |
| title_sort | virucidal pvp copper salt composites against coronavirus produced by electrospinning and electrospraying |
| topic | electrospinning technology polyvinylpyrrolidone copper coronavirus |
| url | https://www.mdpi.com/2073-4360/14/19/4157 |
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