Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Abstract Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of sy...

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Podrobná bibliografie
Hlavní autoři: Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro
Médium: Článek
Jazyk:English
Vydáno: BMC 2021-03-01
Edice:Acta Neuropathologica Communications
Témata:
Alzheimer’s Disease
Β-amyloid
Mouse model
Neurodegeneration
Retina
Tau
On-line přístup:https://doi.org/10.1186/s40478-021-01138-1

Internet

https://doi.org/10.1186/s40478-021-01138-1

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