Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Abstract Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of sy...

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Bibliografski detalji
Glavni autori: Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro
Format: Članak
Jezik:English
Izdano: BMC 2021-03-01
Serija:Acta Neuropathologica Communications
Teme:
Alzheimer’s Disease
Β-amyloid
Mouse model
Neurodegeneration
Retina
Tau
Online pristup:https://doi.org/10.1186/s40478-021-01138-1

Internet

https://doi.org/10.1186/s40478-021-01138-1

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