Fine mapping of the HLA locus in Parkinson’s disease in Europeans

Fine mapping of the HLA locus in Parkinson’s disease in Europeans

Abstract We fine mapped the leukocyte antigen (HLA) region in 13,770 Parkinson’s disease (PD) patients, 20,214 proxy-cases, and 490,861 controls of European origin. Four HLA types were associated with PD after correction for multiple comparisons, HLA-DQA1*03:01, HLA-DQB1*03:02, HLA-DRB1*04:01, and H...

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Main Authors: Eric Yu, Aditya Ambati, Maren Stolp Andersen, Lynne Krohn, Mehrdad A. Estiar, Prabhjyot Saini, Konstantin Senkevich, Yuri L. Sosero, Ashwin Ashok Kumar Sreelatha, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Mathias Toft, Marte K. Viken, Manu Sharma, Cornelis Blauwendraat, Lasse Pihlstrøm, Emmanuel Mignot, Ziv Gan-Or
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00231-5

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