Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020
Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protec...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/10/7/1323 |
| _version_ | 1827688544384057344 |
|---|---|
| author | Shailaja Rao Mallesh Kurakula Nagarjuna Mamidipalli Papireddy Tiyyagura Bhaumik Patel Ravi Manne |
| author_facet | Shailaja Rao Mallesh Kurakula Nagarjuna Mamidipalli Papireddy Tiyyagura Bhaumik Patel Ravi Manne |
| author_sort | Shailaja Rao |
| collection | DOAJ |
| description | Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases. |
| first_indexed | 2024-03-10T09:59:14Z |
| format | Article |
| id | doaj.art-f4f2f3e65fc84da7ad06b8278cb865fd |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T09:59:14Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-f4f2f3e65fc84da7ad06b8278cb865fd2023-11-22T02:07:58ZengMDPI AGPlants2223-77472021-06-01107132310.3390/plants10071323Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020Shailaja Rao0Mallesh Kurakula1Nagarjuna Mamidipalli2Papireddy Tiyyagura3Bhaumik Patel4Ravi Manne5Department of Neurosurgery, Stanford University, Stanford, CA 94305, USADepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USAAnalytical R&D, Akron Inc., Lake Forest, IL 60045, USAAnalytical R&D, BioDuro LLC, San Diego, CA 92121, USAProduct Development Department, Cure Pharmaceutical Corporation, Los Angeles, CA 90025, USAChemtex Environmental Laboratory, Quality Control and Assurance Department, Port Arthur, TX 77642, USARaspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases.https://www.mdpi.com/2223-7747/10/7/1323raspberry ketonehepatoprotectioncardioprotectiongastroprotectionobesitydepigmentation |
| spellingShingle | Shailaja Rao Mallesh Kurakula Nagarjuna Mamidipalli Papireddy Tiyyagura Bhaumik Patel Ravi Manne Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 Plants raspberry ketone hepatoprotection cardioprotection gastroprotection obesity depigmentation |
| title | Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 |
| title_full | Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 |
| title_fullStr | Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 |
| title_full_unstemmed | Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 |
| title_short | Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020 |
| title_sort | pharmacological exploration of phenolic compound raspberry ketone update 2020 |
| topic | raspberry ketone hepatoprotection cardioprotection gastroprotection obesity depigmentation |
| url | https://www.mdpi.com/2223-7747/10/7/1323 |
| work_keys_str_mv | AT shailajarao pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 AT malleshkurakula pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 AT nagarjunamamidipalli pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 AT papireddytiyyagura pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 AT bhaumikpatel pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 AT ravimanne pharmacologicalexplorationofphenoliccompoundraspberryketoneupdate2020 |