The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis
BackgroundAccumulating evidence suggests that patients with nonalcoholic fatty liver disease (NAFLD) have a significantly high risk of incident atrial fibrillation (AF). Systemic inflammation, metabolic disorders and oxidative stress could be the potential mechanisms by which NAFLD drives AF. Monocy...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1127425/full |
| _version_ | 1797858985469018112 |
|---|---|
| author | Leigang Wang Leigang Wang Yao Zhang Yao Zhang Bing Yu Bing Yu Jianqi Zhao Jianqi Zhao Wenjing Zhang Wenjing Zhang Hongxuan Fan Hongxuan Fan Zhaoyu Ren Zhaoyu Ren Bin Liang |
| author_facet | Leigang Wang Leigang Wang Yao Zhang Yao Zhang Bing Yu Bing Yu Jianqi Zhao Jianqi Zhao Wenjing Zhang Wenjing Zhang Hongxuan Fan Hongxuan Fan Zhaoyu Ren Zhaoyu Ren Bin Liang |
| author_sort | Leigang Wang |
| collection | DOAJ |
| description | BackgroundAccumulating evidence suggests that patients with nonalcoholic fatty liver disease (NAFLD) have a significantly high risk of incident atrial fibrillation (AF). Systemic inflammation, metabolic disorders and oxidative stress could be the potential mechanisms by which NAFLD drives AF. Monocyte-to- high-density lipoprotein ratio (MHR) has emerged as a novel biomarker of inflammation and oxidative stress that has not been studied in AF with NAFLD patients. We aimed to investigate the relationship between MHR and the risk of AF among NAFLD patients.MethodsA retrospective analysis was performed for the clinical data of the patients with NAFLD in the Second Hospital of Shanxi Medical University from January 2019 to October 2022, among whom 204 patients with AF were enrolled as NAFLD+AF group and 613 patients without AF were enrolled as NAFLD control, and 152 patients were selected from each group based on propensity score matching (PSM) at a ratio of 1:1 to balance the covariates between groups. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups; the chi-square test or the Fisher’s exact test was used for comparison of categorical data between two groups. Logistic regression analysis was performed to identify the independent predictor for occurrence of AF among NAFLD patients. Trend chi-square test to analyze the prevalence of AF among MHR tertiles, and then the correlation between MHR and the risk of AF confirmed by restricted cubic splines (RCS). The receiver operating characteristic (ROC) curve analysis was used to determine the optimum MHR cutoff value to predict AF.ResultsUnivariate analysis showed that AF patients had higher MHR than non-AF patients (P < 0.001). Meanwhile, compared with pure NAFLD patients, multivariate logistic regression analysis showed that MHR remained to be an independent risk factor for AF after adjusting for confounding risk factors (OR = 10.67, 95% CI 2.17-52.37, P = 0.004). TC、HDL-C were also independent risk factors for AF. Among them, TC and HDL-C are protective factors for AF. The trend chi-square test showed that the risk of AF increased with an increase in MHR (P < 0.05). However, the RCS showed a nonlinear and J-shaped relationship between MHR and the risk of AF (P for non-linearity = 0.023). The occurrence of AF increased with increasing MHR only when MHR > 0.44. The ROC curve showed that MHR combined with traditional risk factors can improve the ability to predict AF.ConclusionMHR is an independently associated with incident AF in patients with NAFLD and show a certain predictive value. |
| first_indexed | 2024-04-09T21:22:14Z |
| format | Article |
| id | doaj.art-f4f485a1c6cd4c62bde1307ced457553 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T21:22:14Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f4f485a1c6cd4c62bde1307ced4575532023-03-28T05:42:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11274251127425The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysisLeigang Wang0Leigang Wang1Yao Zhang2Yao Zhang3Bing Yu4Bing Yu5Jianqi Zhao6Jianqi Zhao7Wenjing Zhang8Wenjing Zhang9Hongxuan Fan10Hongxuan Fan11Zhaoyu Ren12Zhaoyu Ren13Bin Liang14Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaBackgroundAccumulating evidence suggests that patients with nonalcoholic fatty liver disease (NAFLD) have a significantly high risk of incident atrial fibrillation (AF). Systemic inflammation, metabolic disorders and oxidative stress could be the potential mechanisms by which NAFLD drives AF. Monocyte-to- high-density lipoprotein ratio (MHR) has emerged as a novel biomarker of inflammation and oxidative stress that has not been studied in AF with NAFLD patients. We aimed to investigate the relationship between MHR and the risk of AF among NAFLD patients.MethodsA retrospective analysis was performed for the clinical data of the patients with NAFLD in the Second Hospital of Shanxi Medical University from January 2019 to October 2022, among whom 204 patients with AF were enrolled as NAFLD+AF group and 613 patients without AF were enrolled as NAFLD control, and 152 patients were selected from each group based on propensity score matching (PSM) at a ratio of 1:1 to balance the covariates between groups. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups; the chi-square test or the Fisher’s exact test was used for comparison of categorical data between two groups. Logistic regression analysis was performed to identify the independent predictor for occurrence of AF among NAFLD patients. Trend chi-square test to analyze the prevalence of AF among MHR tertiles, and then the correlation between MHR and the risk of AF confirmed by restricted cubic splines (RCS). The receiver operating characteristic (ROC) curve analysis was used to determine the optimum MHR cutoff value to predict AF.ResultsUnivariate analysis showed that AF patients had higher MHR than non-AF patients (P < 0.001). Meanwhile, compared with pure NAFLD patients, multivariate logistic regression analysis showed that MHR remained to be an independent risk factor for AF after adjusting for confounding risk factors (OR = 10.67, 95% CI 2.17-52.37, P = 0.004). TC、HDL-C were also independent risk factors for AF. Among them, TC and HDL-C are protective factors for AF. The trend chi-square test showed that the risk of AF increased with an increase in MHR (P < 0.05). However, the RCS showed a nonlinear and J-shaped relationship between MHR and the risk of AF (P for non-linearity = 0.023). The occurrence of AF increased with increasing MHR only when MHR > 0.44. The ROC curve showed that MHR combined with traditional risk factors can improve the ability to predict AF.ConclusionMHR is an independently associated with incident AF in patients with NAFLD and show a certain predictive value.https://www.frontiersin.org/articles/10.3389/fendo.2023.1127425/fullmonocyte to high-density lipoprotein cholesterol ratioinflammationatrial fibrillationnonalcoholic fatty liver diseasepropensity score matching analysis |
| spellingShingle | Leigang Wang Leigang Wang Yao Zhang Yao Zhang Bing Yu Bing Yu Jianqi Zhao Jianqi Zhao Wenjing Zhang Wenjing Zhang Hongxuan Fan Hongxuan Fan Zhaoyu Ren Zhaoyu Ren Bin Liang The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis Frontiers in Endocrinology monocyte to high-density lipoprotein cholesterol ratio inflammation atrial fibrillation nonalcoholic fatty liver disease propensity score matching analysis |
| title | The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis |
| title_full | The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis |
| title_fullStr | The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis |
| title_full_unstemmed | The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis |
| title_short | The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis |
| title_sort | monocyte to high density lipoprotein ratio is associated with the occurrence of atrial fibrillation among nafld patients a propensity matched analysis |
| topic | monocyte to high-density lipoprotein cholesterol ratio inflammation atrial fibrillation nonalcoholic fatty liver disease propensity score matching analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1127425/full |
| work_keys_str_mv | AT leigangwang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT leigangwang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT yaozhang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT yaozhang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT bingyu themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT bingyu themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT jianqizhao themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT jianqizhao themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT wenjingzhang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT wenjingzhang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT hongxuanfan themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT hongxuanfan themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT zhaoyuren themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT zhaoyuren themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT binliang themonocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT leigangwang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT leigangwang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT yaozhang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT yaozhang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT bingyu monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT bingyu monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT jianqizhao monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT jianqizhao monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT wenjingzhang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT wenjingzhang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT hongxuanfan monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT hongxuanfan monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT zhaoyuren monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT zhaoyuren monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis AT binliang monocytetohighdensitylipoproteinratioisassociatedwiththeoccurrenceofatrialfibrillationamongnafldpatientsapropensitymatchedanalysis |