Serum hydrogen sulphide levels in acute asthmatic children: a case control study
Abstract Background It’s thought that respiratory epithelium-produced reduced hydrogen sulphide (H2S) plays a role in the pathophysiology of acute asthma. In this case–control research, blood H2S levels were examined between matched acutely asthmatic children and non-asthmatic controls. The grade of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-06-01
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| Series: | Egyptian Pediatric Association Gazette |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43054-023-00177-8 |
| _version_ | 1827910982506119168 |
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| author | Mohamed Abdallah Abd El Megied Mohammad Abdel Fattah Abdel Motey Ahmed Salama Amen |
| author_facet | Mohamed Abdallah Abd El Megied Mohammad Abdel Fattah Abdel Motey Ahmed Salama Amen |
| author_sort | Mohamed Abdallah Abd El Megied |
| collection | DOAJ |
| description | Abstract Background It’s thought that respiratory epithelium-produced reduced hydrogen sulphide (H2S) plays a role in the pathophysiology of acute asthma. In this case–control research, blood H2S levels were examined between matched acutely asthmatic children and non-asthmatic controls. The grade of acute asthma, vital signs and absolute eosinophilic count in the asthmatic children were likewise associated with the blood H2S level. Methods Forty Egyptian asthmatic children had visited the emergency room and forty age- and sex-matched non-asthmatic controls had their blood H2S levels measured using enzyme-linked immunosorbent assay (ELISA). Results The serum H2S in the two groups did not differ statistically significantly. Serum H2S and respiratory rate showed a moderately significant inverse connection (r = -0.325, p = 0.041). However, serum H2S and other clinical or laboratory variables exhibited no meaningful relationships. Patients' absolute and percentage eosinophil counts were considerably higher than healthy controls. Serum H2S exhibited a sensitivity of 50% and a specificity of 32.5% for identifying children with acute asthma from non-asthmatic children. Conclusion Children with asthma and those without asthma had similar serum H2S levels. It has a lousy relationship with respiratory rate. It is indicated that it is an inadequate screening and diagnostic tool since it has low sensitivity (50%) and specificity (32.5%) in differentiating acute asthmatic children. |
| first_indexed | 2024-03-13T01:56:57Z |
| format | Article |
| id | doaj.art-f4f63eda7e84402bba3bbbd95c510464 |
| institution | Directory Open Access Journal |
| issn | 2090-9942 |
| language | English |
| last_indexed | 2024-03-13T01:56:57Z |
| publishDate | 2023-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj.art-f4f63eda7e84402bba3bbbd95c5104642023-07-02T11:10:19ZengSpringerOpenEgyptian Pediatric Association Gazette2090-99422023-06-017111710.1186/s43054-023-00177-8Serum hydrogen sulphide levels in acute asthmatic children: a case control studyMohamed Abdallah Abd El Megied0Mohammad Abdel Fattah Abdel Motey1Ahmed Salama Amen2Department of Pediatrics1, Faculty of Medicine, Cairo UniversityDepartment of Pediatrics1, Faculty of Medicine, Cairo UniversityMinistry of Health and PopulationAbstract Background It’s thought that respiratory epithelium-produced reduced hydrogen sulphide (H2S) plays a role in the pathophysiology of acute asthma. In this case–control research, blood H2S levels were examined between matched acutely asthmatic children and non-asthmatic controls. The grade of acute asthma, vital signs and absolute eosinophilic count in the asthmatic children were likewise associated with the blood H2S level. Methods Forty Egyptian asthmatic children had visited the emergency room and forty age- and sex-matched non-asthmatic controls had their blood H2S levels measured using enzyme-linked immunosorbent assay (ELISA). Results The serum H2S in the two groups did not differ statistically significantly. Serum H2S and respiratory rate showed a moderately significant inverse connection (r = -0.325, p = 0.041). However, serum H2S and other clinical or laboratory variables exhibited no meaningful relationships. Patients' absolute and percentage eosinophil counts were considerably higher than healthy controls. Serum H2S exhibited a sensitivity of 50% and a specificity of 32.5% for identifying children with acute asthma from non-asthmatic children. Conclusion Children with asthma and those without asthma had similar serum H2S levels. It has a lousy relationship with respiratory rate. It is indicated that it is an inadequate screening and diagnostic tool since it has low sensitivity (50%) and specificity (32.5%) in differentiating acute asthmatic children.https://doi.org/10.1186/s43054-023-00177-8Acute asthmaChildrenHydrogen sulphide |
| spellingShingle | Mohamed Abdallah Abd El Megied Mohammad Abdel Fattah Abdel Motey Ahmed Salama Amen Serum hydrogen sulphide levels in acute asthmatic children: a case control study Egyptian Pediatric Association Gazette Acute asthma Children Hydrogen sulphide |
| title | Serum hydrogen sulphide levels in acute asthmatic children: a case control study |
| title_full | Serum hydrogen sulphide levels in acute asthmatic children: a case control study |
| title_fullStr | Serum hydrogen sulphide levels in acute asthmatic children: a case control study |
| title_full_unstemmed | Serum hydrogen sulphide levels in acute asthmatic children: a case control study |
| title_short | Serum hydrogen sulphide levels in acute asthmatic children: a case control study |
| title_sort | serum hydrogen sulphide levels in acute asthmatic children a case control study |
| topic | Acute asthma Children Hydrogen sulphide |
| url | https://doi.org/10.1186/s43054-023-00177-8 |
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