The continual reassessment method for multiple toxicity grades: a bayesian model selection approach.

The continual reassessment method for multiple toxicity grades: a bayesian model selection approach.

Grade information has been considered in Yuan et al. (2007) wherein they proposed a Quasi-CRM method to incorporate the grade toxicity information in phase I trials. A potential problem with the Quasi-CRM model is that the choice of skeleton may dramatically vary the performance of the CRM model, wh...

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Bibliographic Details
Main Authors: Haitao Pan, Cailin Zhu, Feng Zhang, Ying Yuan, Shemin Zhang, Wenhong Zhang, Chanjuan Li, Ling Wang, Jielai Xia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4038518?pdf=render

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