Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?
Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This technological advance is a decisive jump in the tech...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1266397/full |
| _version_ | 1797658127822225408 |
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| author | Jack M. Shireman Lingxin Cheng Amiti Goel Diogo Moniz Garcia Sanil Partha Alfredo Quiñones-Hinojosa Christina Kendziorski Mahua Dey |
| author_facet | Jack M. Shireman Lingxin Cheng Amiti Goel Diogo Moniz Garcia Sanil Partha Alfredo Quiñones-Hinojosa Christina Kendziorski Mahua Dey |
| author_sort | Jack M. Shireman |
| collection | DOAJ |
| description | Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This technological advance is a decisive jump in the technological evolution that is revolutionizing studies of tissue structure and function in health and disease through the introduction of an entirely new dimension of data, spatial context. Perhaps the organ within the body that relies most on spatial organization is the brain. The central nervous system’s complex microenvironmental and spatial architecture is tightly regulated during development, is maintained in health, and is detrimental when disturbed by pathologies. This inherent spatial complexity of the central nervous system makes it an exciting organ to study using spatial transcriptomics for pathologies primarily affecting the brain, of which Glioblastoma is one of the worst. Glioblastoma is a hyper-aggressive, incurable, neoplasm and has been hypothesized to not only integrate into the spatial architecture of the surrounding brain, but also possess an architecture of its own that might be actively remodeling the surrounding brain. In this review we will examine the current landscape of spatial transcriptomics in glioblastoma, outline novel findings emerging from the rising use of spatial transcriptomics, and discuss future directions and ultimate clinical/translational avenues. |
| first_indexed | 2024-03-11T17:54:39Z |
| format | Article |
| id | doaj.art-f4f8d78bcd6644b4a875683e92ef2310 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T17:54:39Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f4f8d78bcd6644b4a875683e92ef23102023-10-17T20:28:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12663971266397Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?Jack M. Shireman0Lingxin Cheng1Amiti Goel2Diogo Moniz Garcia3Sanil Partha4Alfredo Quiñones-Hinojosa5Christina Kendziorski6Mahua Dey7Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison (UW) Carbone Cancer Center, Madison, WI, United StatesDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison (UW) Carbone Cancer Center, Madison, WI, United StatesDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison (UW) Carbone Cancer Center, Madison, WI, United StatesDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison (UW) Carbone Cancer Center, Madison, WI, United StatesSpatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This technological advance is a decisive jump in the technological evolution that is revolutionizing studies of tissue structure and function in health and disease through the introduction of an entirely new dimension of data, spatial context. Perhaps the organ within the body that relies most on spatial organization is the brain. The central nervous system’s complex microenvironmental and spatial architecture is tightly regulated during development, is maintained in health, and is detrimental when disturbed by pathologies. This inherent spatial complexity of the central nervous system makes it an exciting organ to study using spatial transcriptomics for pathologies primarily affecting the brain, of which Glioblastoma is one of the worst. Glioblastoma is a hyper-aggressive, incurable, neoplasm and has been hypothesized to not only integrate into the spatial architecture of the surrounding brain, but also possess an architecture of its own that might be actively remodeling the surrounding brain. In this review we will examine the current landscape of spatial transcriptomics in glioblastoma, outline novel findings emerging from the rising use of spatial transcriptomics, and discuss future directions and ultimate clinical/translational avenues.https://www.frontiersin.org/articles/10.3389/fonc.2023.1266397/fullglioblasomaspatial transcriptomicsbioinformaticscancerpersonalized medicine |
| spellingShingle | Jack M. Shireman Lingxin Cheng Amiti Goel Diogo Moniz Garcia Sanil Partha Alfredo Quiñones-Hinojosa Christina Kendziorski Mahua Dey Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? Frontiers in Oncology glioblasoma spatial transcriptomics bioinformatics cancer personalized medicine |
| title | Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? |
| title_full | Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? |
| title_fullStr | Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? |
| title_full_unstemmed | Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? |
| title_short | Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? |
| title_sort | spatial transcriptomics in glioblastoma is knowing the right zip code the key to the next therapeutic breakthrough |
| topic | glioblasoma spatial transcriptomics bioinformatics cancer personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1266397/full |
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