Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer
This study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide w...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2021-08-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/64025 |
| _version_ | 1831570341138268160 |
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| author | Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni |
| author_facet | Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni |
| author_sort | Lasmaryna Sirumapea |
| collection | DOAJ |
| description | This study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide were applied as functional monomer, crosslinker agent, initiator, and solvent, respectively. Scanning electron microscopy, thermogravimetric analysis, Brunauer-Emmett-Teller analysis, and Fourier transform infrared spectroscopy were used to characterize the morphology, pore size, and structure of imprinted polymers. The maximum adsorption capacity was achieved at pH = 3, after 4 h contacted, under 150 rpm, and 25 mg of polymer applied. The maximum adsorption capacity of MeIP for meropenem was 51.963 mg/L; the synthesized polymer had superior selectivity to meropenem compared to that of the other antibiotics (imprinting factor, IF = 2.58). Furthermore, the thermodynamic and kinetic analyses indicated that the results were in accord with the Freundlich model and the pseudo-second-order kinetic model, respectively. MeIP was selective in batch adsorption, and molecularly imprinted solid-phase extraction protocols were selective to meropenem. It was then applied to analyze meropenem in human blood plasma and resulted in 78.52 ± 2.71 of recovery. |
| first_indexed | 2024-12-17T12:49:40Z |
| format | Article |
| id | doaj.art-f4fafb6d419c42c0829fca1305f0fd8f |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-17T12:49:40Z |
| publishDate | 2021-08-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-f4fafb6d419c42c0829fca1305f0fd8f2022-12-21T21:47:39ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782021-08-012151167117910.22146/ijc.6402530401Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted PolymerLasmaryna Sirumapea0Mohammad Ali Zulfikar1Muhammad Bachri Amran2Anita Alni3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, West Java, Indonesia; STIFI Bhakti Pertiwi Palembang, Jl. Ariodillah III No. 22, Palembang 30128, South Sumatera, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, West Java, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, West Java, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, West Java, IndonesiaThis study employed a selective and high adsorption performance for meropenem. Molecularly imprinted polymer for meropenem (MeIP) as the selective sorbent was prepared through a bulk polymerization reaction. Methacrylic acid, ethylene glycol dimethacrylate, benzoyl peroxide, and dimethyl sulfoxide were applied as functional monomer, crosslinker agent, initiator, and solvent, respectively. Scanning electron microscopy, thermogravimetric analysis, Brunauer-Emmett-Teller analysis, and Fourier transform infrared spectroscopy were used to characterize the morphology, pore size, and structure of imprinted polymers. The maximum adsorption capacity was achieved at pH = 3, after 4 h contacted, under 150 rpm, and 25 mg of polymer applied. The maximum adsorption capacity of MeIP for meropenem was 51.963 mg/L; the synthesized polymer had superior selectivity to meropenem compared to that of the other antibiotics (imprinting factor, IF = 2.58). Furthermore, the thermodynamic and kinetic analyses indicated that the results were in accord with the Freundlich model and the pseudo-second-order kinetic model, respectively. MeIP was selective in batch adsorption, and molecularly imprinted solid-phase extraction protocols were selective to meropenem. It was then applied to analyze meropenem in human blood plasma and resulted in 78.52 ± 2.71 of recovery.https://jurnal.ugm.ac.id/ijc/article/view/64025meropenemmolecularly imprinted polymerselectivesolid-phase extraction |
| spellingShingle | Lasmaryna Sirumapea Mohammad Ali Zulfikar Muhammad Bachri Amran Anita Alni Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer Indonesian Journal of Chemistry meropenem molecularly imprinted polymer selective solid-phase extraction |
| title | Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer |
| title_full | Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer |
| title_fullStr | Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer |
| title_full_unstemmed | Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer |
| title_short | Selective Solid-Phase Extraction of Meropenem from Human Blood Plasma Using a Molecularly Imprinted Polymer |
| title_sort | selective solid phase extraction of meropenem from human blood plasma using a molecularly imprinted polymer |
| topic | meropenem molecularly imprinted polymer selective solid-phase extraction |
| url | https://jurnal.ugm.ac.id/ijc/article/view/64025 |
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