Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production
The cytokine-activated Janus kinase (JAK)—signal transducer and activator of transcription (STAT) pathway is a sequence of communications between proteins in a cell, and it is associated with various processes such as cell division, apoptosis, mammary gland development, lactation, anti-inflammation,...
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MDPI AG
2020-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/11/2107 |
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| author | Muhammad Zahoor Khan Adnan Khan Jianxin Xiao Yulin Ma Jiaying Ma Jian Gao Zhijun Cao |
| author_facet | Muhammad Zahoor Khan Adnan Khan Jianxin Xiao Yulin Ma Jiaying Ma Jian Gao Zhijun Cao |
| author_sort | Muhammad Zahoor Khan |
| collection | DOAJ |
| description | The cytokine-activated Janus kinase (JAK)—signal transducer and activator of transcription (STAT) pathway is a sequence of communications between proteins in a cell, and it is associated with various processes such as cell division, apoptosis, mammary gland development, lactation, anti-inflammation, and immunity. The pathway is involved in transferring information from receptors on the cell surface to the cell nucleus, resulting in the regulation of genes through transcription. The Janus kinase 2 (<i>JAK2</i>), signal transducer and activator of transcription A and B (STAT5 A & B), STAT1, and cytokine signaling suppressor 3 (<i>SOCS3</i>) are the key members of the JAK-STAT pathway. Interestingly, prolactin (Prl) also uses the JAK-STAT pathway to regulate milk production traits in dairy cattle. The activation of <i>JAK2</i> and <i>STATs</i> genes has a critical role in milk production and mastitis resistance. The upregulation of <i>SOCS3</i> in bovine mammary epithelial cells inhibits the activation of <i>JAK2</i> and <i>STATs</i> genes, which promotes mastitis development and reduces the lactational performance of dairy cattle. In the current review, we highlight the recent development in the knowledge of JAK-STAT, which will enhance our ability to devise therapeutic strategies for bovine mastitis control. Furthermore, the review also explores the role of the JAK-STAT pathway in the regulation of milk production in dairy cattle. |
| first_indexed | 2024-03-10T14:53:24Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T14:53:24Z |
| publishDate | 2020-11-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-f4fd40d5768e4c058498d2010fd9af5f2023-11-20T20:51:57ZengMDPI AGAnimals2076-26152020-11-011011210710.3390/ani10112107Role of the JAK-STAT Pathway in Bovine Mastitis and Milk ProductionMuhammad Zahoor Khan0Adnan Khan1Jianxin Xiao2Yulin Ma3Jiaying Ma4Jian Gao5Zhijun Cao6State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Animal Genetics, Breeding, and Reproduction, Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaThe cytokine-activated Janus kinase (JAK)—signal transducer and activator of transcription (STAT) pathway is a sequence of communications between proteins in a cell, and it is associated with various processes such as cell division, apoptosis, mammary gland development, lactation, anti-inflammation, and immunity. The pathway is involved in transferring information from receptors on the cell surface to the cell nucleus, resulting in the regulation of genes through transcription. The Janus kinase 2 (<i>JAK2</i>), signal transducer and activator of transcription A and B (STAT5 A & B), STAT1, and cytokine signaling suppressor 3 (<i>SOCS3</i>) are the key members of the JAK-STAT pathway. Interestingly, prolactin (Prl) also uses the JAK-STAT pathway to regulate milk production traits in dairy cattle. The activation of <i>JAK2</i> and <i>STATs</i> genes has a critical role in milk production and mastitis resistance. The upregulation of <i>SOCS3</i> in bovine mammary epithelial cells inhibits the activation of <i>JAK2</i> and <i>STATs</i> genes, which promotes mastitis development and reduces the lactational performance of dairy cattle. In the current review, we highlight the recent development in the knowledge of JAK-STAT, which will enhance our ability to devise therapeutic strategies for bovine mastitis control. Furthermore, the review also explores the role of the JAK-STAT pathway in the regulation of milk production in dairy cattle.https://www.mdpi.com/2076-2615/10/11/2107bovine mastitisJAK-STAT pathway<i>JAK2</i><i>STATs</i><i>SOCS3</i>immunity |
| spellingShingle | Muhammad Zahoor Khan Adnan Khan Jianxin Xiao Yulin Ma Jiaying Ma Jian Gao Zhijun Cao Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production Animals bovine mastitis JAK-STAT pathway <i>JAK2</i> <i>STATs</i> <i>SOCS3</i> immunity |
| title | Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production |
| title_full | Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production |
| title_fullStr | Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production |
| title_full_unstemmed | Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production |
| title_short | Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production |
| title_sort | role of the jak stat pathway in bovine mastitis and milk production |
| topic | bovine mastitis JAK-STAT pathway <i>JAK2</i> <i>STATs</i> <i>SOCS3</i> immunity |
| url | https://www.mdpi.com/2076-2615/10/11/2107 |
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