Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia
Abstract Background Non–small-cell lung cancer (NSCLC) has been reported to develop in patients with interstitial pneumonia (IP); however, clinical, radiological, and pathological features remain to be elucidated. Methods We retrieved the records of 120 consecutive NSCLC patients associated with IP...
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| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-020-01347-9 |
| _version_ | 1828542731103764480 |
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| author | Kazumasa Ogawa Hironori Uruga Takeshi Fujii Sakashi Fujimori Tadasu Kohno Atsuko Kurosaki Kazuma Kishi Shinji Abe |
| author_facet | Kazumasa Ogawa Hironori Uruga Takeshi Fujii Sakashi Fujimori Tadasu Kohno Atsuko Kurosaki Kazuma Kishi Shinji Abe |
| author_sort | Kazumasa Ogawa |
| collection | DOAJ |
| description | Abstract Background Non–small-cell lung cancer (NSCLC) has been reported to develop in patients with interstitial pneumonia (IP); however, clinical, radiological, and pathological features remain to be elucidated. Methods We retrieved the records of 120 consecutive NSCLC patients associated with IP who underwent surgery at Toranomon Hospital between June 2011 and May 2017. We classified the patients into three groups according to NSCLC location using high-resolution computed tomography: group A, within a fibrotic shadow and/or at the interface of a fibrotic shadow and normal lung; group B, within emphysematous tissue and/or at the interface of emphysematous tissue and normal lung; and group C, within normal lung. In 64 patients, programmed death ligand-1 (PD-L1) status was assessed with immunohistostaining. Results Most of the patients (89; 70%) were classified as group A. This group tended to have squamous cell carcinoma with the usual interstitial pneumonia (UIP). These cancers were located mainly in the lower lobes and seven of the eight postoperative acute exacerbations (pAE) of IP developed in this group. NSCLC in the group B were mainly squamous cell carcinomas located in the upper lobes. No patient with PD-L1 negative was classified into group B. None of the patients in group C showed UIP. and most of the cancers were adenocarcinoma. The frequency of epidermal growth factor receptor mutation-positive NSCLC was the highest in this group. Conclusions The three groups each showed characteristic features in terms of tumor location, histopathology, PD-L1 expression, and frequency of pAEof IP. |
| first_indexed | 2024-12-12T02:02:08Z |
| format | Article |
| id | doaj.art-f4fe319d436445c4b92de36f0d7c968e |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-12T02:02:08Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-f4fe319d436445c4b92de36f0d7c968e2022-12-22T00:42:09ZengBMCBMC Pulmonary Medicine1471-24662020-11-0120111010.1186/s12890-020-01347-9Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumoniaKazumasa Ogawa0Hironori Uruga1Takeshi Fujii2Sakashi Fujimori3Tadasu Kohno4Atsuko Kurosaki5Kazuma Kishi6Shinji Abe7Department of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalOkinaka Memorial Institute for Medical ResearchDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Tokyo Medical UniversityAbstract Background Non–small-cell lung cancer (NSCLC) has been reported to develop in patients with interstitial pneumonia (IP); however, clinical, radiological, and pathological features remain to be elucidated. Methods We retrieved the records of 120 consecutive NSCLC patients associated with IP who underwent surgery at Toranomon Hospital between June 2011 and May 2017. We classified the patients into three groups according to NSCLC location using high-resolution computed tomography: group A, within a fibrotic shadow and/or at the interface of a fibrotic shadow and normal lung; group B, within emphysematous tissue and/or at the interface of emphysematous tissue and normal lung; and group C, within normal lung. In 64 patients, programmed death ligand-1 (PD-L1) status was assessed with immunohistostaining. Results Most of the patients (89; 70%) were classified as group A. This group tended to have squamous cell carcinoma with the usual interstitial pneumonia (UIP). These cancers were located mainly in the lower lobes and seven of the eight postoperative acute exacerbations (pAE) of IP developed in this group. NSCLC in the group B were mainly squamous cell carcinomas located in the upper lobes. No patient with PD-L1 negative was classified into group B. None of the patients in group C showed UIP. and most of the cancers were adenocarcinoma. The frequency of epidermal growth factor receptor mutation-positive NSCLC was the highest in this group. Conclusions The three groups each showed characteristic features in terms of tumor location, histopathology, PD-L1 expression, and frequency of pAEof IP.http://link.springer.com/article/10.1186/s12890-020-01347-9Interstitial lung diseaseNon–small-cell lung cancerVideo-assisted thoracic surgeryAcute exacerbationCancer locationPulmonary emphysema |
| spellingShingle | Kazumasa Ogawa Hironori Uruga Takeshi Fujii Sakashi Fujimori Tadasu Kohno Atsuko Kurosaki Kazuma Kishi Shinji Abe Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia BMC Pulmonary Medicine Interstitial lung disease Non–small-cell lung cancer Video-assisted thoracic surgery Acute exacerbation Cancer location Pulmonary emphysema |
| title | Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia |
| title_full | Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia |
| title_fullStr | Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia |
| title_full_unstemmed | Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia |
| title_short | Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia |
| title_sort | characteristics of non small cell lung cancer with interstitial pneumonia variation in cancer location histopathology and frequency of postoperative acute exacerbations in interstitial pneumonia |
| topic | Interstitial lung disease Non–small-cell lung cancer Video-assisted thoracic surgery Acute exacerbation Cancer location Pulmonary emphysema |
| url | http://link.springer.com/article/10.1186/s12890-020-01347-9 |
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