Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Background: In the human central nervous system (CN), resting astrocytes do not visually show endothelin-1 (ET-1)-like immunoreactivity. In patients with multiple sclerosis (MS), an inflammatory disorder of the CNS, high levels of ET-1 are found in reactive astrocytes in demyelinated plaques. ET-1 m...

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Bibliografiske detaljer
Main Authors:	Stéphanie Hostenbach, Miguel D’Haeseleer, Ron Kooijman, Jacques De Keyser
Format:	Article
Sprog:	English
Udgivet:	Frontiers Media S.A. 2020-01-01
Serier:	Frontiers in Pharmacology
Fag:	multiple sclerosis endothelin-1 astrocytes cytokines inflammation fluoxetine
Online adgang:	https://www.frontiersin.org/article/10.3389/fphar.2019.01491/full

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