Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications
Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sciendo
2012-12-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/v10034-012-0024-9 |
| _version_ | 1797718712979030016 |
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| author | Dörk Thilo Bogdanova N |
| author_facet | Dörk Thilo Bogdanova N |
| author_sort | Dörk Thilo |
| collection | DOAJ |
| description | Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy. |
| first_indexed | 2024-03-12T08:54:23Z |
| format | Article |
| id | doaj.art-f4fe89a4dec84adba2c38d83e3661b1e |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T08:54:23Z |
| publishDate | 2012-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-f4fe89a4dec84adba2c38d83e3661b1e2023-09-02T16:10:14ZengSciendoBalkan Journal of Medical Genetics1311-01602012-12-0115Supplement758010.2478/v10034-012-0024-9Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical ImplicationsDörk Thilo0Bogdanova N1Hannover Medical School, Gynaecology Research Unit (OE 6411), Carl-Neuberg-Str. 1, D-30625 Hannover, GermanyClinic of Radiation Oncology, Hannover Medical School, Hannover, GermanyOver the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy.https://doi.org/10.2478/v10034-012-0024-9breast carcinomaovarian carcinomagerm-line mutationschromosomal instability |
| spellingShingle | Dörk Thilo Bogdanova N Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications Balkan Journal of Medical Genetics breast carcinoma ovarian carcinoma germ-line mutations chromosomal instability |
| title | Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications |
| title_full | Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications |
| title_fullStr | Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications |
| title_full_unstemmed | Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications |
| title_short | Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications |
| title_sort | molecular genetics of breast and ovarian cancer recent advances and clinical implications |
| topic | breast carcinoma ovarian carcinoma germ-line mutations chromosomal instability |
| url | https://doi.org/10.2478/v10034-012-0024-9 |
| work_keys_str_mv | AT dorkthilo moleculargeneticsofbreastandovariancancerrecentadvancesandclinicalimplications AT bogdanovan moleculargeneticsofbreastandovariancancerrecentadvancesandclinicalimplications |