Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review

Stevia rebaudiana Bertoni is a small perennial shrub of the Asteraceae (Compositae) family that is native to South America, particularly Brazil and Paraguay, where it is known as “stevia” or “honey leaf” for its powerful sweetness. Several studies have suggested that in addition to their sweetness,...

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Main Authors: Gianmaria Fabrizio Ferrazzano, Tiziana Cantile, Brunella Alcidi, Marco Coda, Aniello Ingenito, Armando Zarrelli, Giovanni Di Fabio, Antonino Pollio
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/1/38
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author Gianmaria Fabrizio Ferrazzano
Tiziana Cantile
Brunella Alcidi
Marco Coda
Aniello Ingenito
Armando Zarrelli
Giovanni Di Fabio
Antonino Pollio
author_facet Gianmaria Fabrizio Ferrazzano
Tiziana Cantile
Brunella Alcidi
Marco Coda
Aniello Ingenito
Armando Zarrelli
Giovanni Di Fabio
Antonino Pollio
author_sort Gianmaria Fabrizio Ferrazzano
collection DOAJ
description Stevia rebaudiana Bertoni is a small perennial shrub of the Asteraceae (Compositae) family that is native to South America, particularly Brazil and Paraguay, where it is known as “stevia” or “honey leaf” for its powerful sweetness. Several studies have suggested that in addition to their sweetness, steviosides and their related compounds, including rebaudioside A and isosteviol, may offer additional therapeutic benefits. These benefits include anti-hyperglycaemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions. Additionally, critical analysis of the literature supports the anti-bacterial role of steviosides on oral bacteria flora. The aim of this review is to show the emerging results regarding the anti-cariogenic properties of S. rebaudiana Bertoni. Data shown in the present paper provide evidence that stevioside extracts from S. rebaudiana are not cariogenic. Future research should be focused on in vivo studies to evaluate the effects on dental caries of regular consumption of S. rebaudiana extract-based products.
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spelling doaj.art-f500d12dea784cfdac7b0d9d24e0dc352022-12-22T03:38:02ZengMDPI AGMolecules1420-30492015-12-012113810.3390/molecules21010038molecules21010038Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A ReviewGianmaria Fabrizio Ferrazzano0Tiziana Cantile1Brunella Alcidi2Marco Coda3Aniello Ingenito4Armando Zarrelli5Giovanni Di Fabio6Antonino Pollio7Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, ItalyDepartment of Chemical Sciences, Complesso Universitario di Monte Sant’Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, ItalyDepartment of Chemical Sciences, Complesso Universitario di Monte Sant’Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, ItalyDepartment of Biology, Complesso Universitario di Monte Sant’Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, ItalyStevia rebaudiana Bertoni is a small perennial shrub of the Asteraceae (Compositae) family that is native to South America, particularly Brazil and Paraguay, where it is known as “stevia” or “honey leaf” for its powerful sweetness. Several studies have suggested that in addition to their sweetness, steviosides and their related compounds, including rebaudioside A and isosteviol, may offer additional therapeutic benefits. These benefits include anti-hyperglycaemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions. Additionally, critical analysis of the literature supports the anti-bacterial role of steviosides on oral bacteria flora. The aim of this review is to show the emerging results regarding the anti-cariogenic properties of S. rebaudiana Bertoni. Data shown in the present paper provide evidence that stevioside extracts from S. rebaudiana are not cariogenic. Future research should be focused on in vivo studies to evaluate the effects on dental caries of regular consumption of S. rebaudiana extract-based products.http://www.mdpi.com/1420-3049/21/1/38Stevia rebaudiana Bertonidental cariessweetener
spellingShingle Gianmaria Fabrizio Ferrazzano
Tiziana Cantile
Brunella Alcidi
Marco Coda
Aniello Ingenito
Armando Zarrelli
Giovanni Di Fabio
Antonino Pollio
Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
Molecules
Stevia rebaudiana Bertoni
dental caries
sweetener
title Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
title_full Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
title_fullStr Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
title_full_unstemmed Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
title_short Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review
title_sort is stevia rebaudiana bertoni a non cariogenic sweetener a review
topic Stevia rebaudiana Bertoni
dental caries
sweetener
url http://www.mdpi.com/1420-3049/21/1/38
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