Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan

Abstract Purpose The purpose of this study is to compare anthropometric measurements between term singletons conceived via fresh embryo transfer (FreET) and frozen embryo transfer (FET) and those born via natural conception (NC) or fertility treatments milder than assisted reproductive technology (n...

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Main Authors: Keiko Ueno, Junya Kojima, Kohta Suzuki, Akira Kuwahara, Yasuhiko Higuchi, Atsushi Tanaka, Takafumi Utsunomiya, Yasuyuki Mio, Hirotaka Nishi, Yasunori Yoshimura, Minoru Irahara, Naoaki Kuji
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Reproductive Medicine and Biology
Subjects:
Online Access:https://doi.org/10.1002/rmb2.12506
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author Keiko Ueno
Junya Kojima
Kohta Suzuki
Akira Kuwahara
Yasuhiko Higuchi
Atsushi Tanaka
Takafumi Utsunomiya
Yasuyuki Mio
Hirotaka Nishi
Yasunori Yoshimura
Minoru Irahara
Naoaki Kuji
author_facet Keiko Ueno
Junya Kojima
Kohta Suzuki
Akira Kuwahara
Yasuhiko Higuchi
Atsushi Tanaka
Takafumi Utsunomiya
Yasuyuki Mio
Hirotaka Nishi
Yasunori Yoshimura
Minoru Irahara
Naoaki Kuji
author_sort Keiko Ueno
collection DOAJ
description Abstract Purpose The purpose of this study is to compare anthropometric measurements between term singletons conceived via fresh embryo transfer (FreET) and frozen embryo transfer (FET) and those born via natural conception (NC) or fertility treatments milder than assisted reproductive technology (non‐ART) at 6 years of age. Methods A total of 8149 children were enrolled, and questionnaires about anthropometric measures (weight, height, BMI) were addressed to parents, when the children were 1.5, 3, and 6 years of age. A total of 3299 term singletons were enrolled at birth: 533, 476, 916, and 1374 in the NC, non‐ART, FreET, and FET groups, respectively. Results A total of 1635 term singletons (290, 176, 467, and 702 in the NC, non‐ART, FreET, and FET groups respectively) were enrolled until 6 years of age (follow‐up rate, approximately 50%). When non‐ART group was used as control, the FreET children were 1.0 cm taller than the non‐ART children at 6 years of age, after adjusting for confounding factors. However, no differences were observed in the anthropometric data among the non‐ART, ART, and NC children at 6 years of age. Conclusion At 6 years of age, term singletons were taller in the FreET group than in the non‐ART group, after adjusting for confounders.
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spelling doaj.art-f50230c29c1b40e39e45d79e73f49fb52023-12-26T04:30:45ZengWileyReproductive Medicine and Biology1445-57811447-05782023-01-01221n/an/a10.1002/rmb2.12506Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in JapanKeiko Ueno0Junya Kojima1Kohta Suzuki2Akira Kuwahara3Yasuhiko Higuchi4Atsushi Tanaka5Takafumi Utsunomiya6Yasuyuki Mio7Hirotaka Nishi8Yasunori Yoshimura9Minoru Irahara10Naoaki Kuji11Department of Obstetrics and Gynecology Tokyo Medical University Tokyo JapanDepartment of Obstetrics and Gynecology Tokyo Medical University Tokyo JapanDepartment of Health and Psychosocial Medicine Aichi Medical University School of Medicine Nagakute Aichi JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima‐shi Tokushima JapanSeibo Hospital Tokyo JapanSaint Mother Obstetrics and Gynecology Clinic and Institute for Assisted Reproductive Technologies Kitakyushu‐shi Fukuoka JapanSt. Luke Clinic Oita‐shi Oita JapanMio Fertility Clinic Yonago‐shi Tottori JapanDepartment of Obstetrics and Gynecology Tokyo Medical University Tokyo JapanDepartment of Obstetrics and Gynecology Keio University School of Medicine Tokyo JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima‐shi Tokushima JapanDepartment of Obstetrics and Gynecology Tokyo Medical University Tokyo JapanAbstract Purpose The purpose of this study is to compare anthropometric measurements between term singletons conceived via fresh embryo transfer (FreET) and frozen embryo transfer (FET) and those born via natural conception (NC) or fertility treatments milder than assisted reproductive technology (non‐ART) at 6 years of age. Methods A total of 8149 children were enrolled, and questionnaires about anthropometric measures (weight, height, BMI) were addressed to parents, when the children were 1.5, 3, and 6 years of age. A total of 3299 term singletons were enrolled at birth: 533, 476, 916, and 1374 in the NC, non‐ART, FreET, and FET groups, respectively. Results A total of 1635 term singletons (290, 176, 467, and 702 in the NC, non‐ART, FreET, and FET groups respectively) were enrolled until 6 years of age (follow‐up rate, approximately 50%). When non‐ART group was used as control, the FreET children were 1.0 cm taller than the non‐ART children at 6 years of age, after adjusting for confounding factors. However, no differences were observed in the anthropometric data among the non‐ART, ART, and NC children at 6 years of age. Conclusion At 6 years of age, term singletons were taller in the FreET group than in the non‐ART group, after adjusting for confounders.https://doi.org/10.1002/rmb2.12506anthropometric measurementsassisted reproductive technologyfresh embryo transferfrozen–thawed embryo transfernatural conception
spellingShingle Keiko Ueno
Junya Kojima
Kohta Suzuki
Akira Kuwahara
Yasuhiko Higuchi
Atsushi Tanaka
Takafumi Utsunomiya
Yasuyuki Mio
Hirotaka Nishi
Yasunori Yoshimura
Minoru Irahara
Naoaki Kuji
Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
Reproductive Medicine and Biology
anthropometric measurements
assisted reproductive technology
fresh embryo transfer
frozen–thawed embryo transfer
natural conception
title Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
title_full Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
title_fullStr Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
title_full_unstemmed Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
title_short Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan
title_sort anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer a multicenter prospective study in japan
topic anthropometric measurements
assisted reproductive technology
fresh embryo transfer
frozen–thawed embryo transfer
natural conception
url https://doi.org/10.1002/rmb2.12506
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