Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)

Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)

Background: The 5’-C-phosphate-G-3’ island methylator phenotype (CIMP) is a specific phenotype of colorectal cancer (CRC) associated with microsatellite instability-high (MSI-high) tumors. Methods: In this study, we determined the CIMP status using eight methylation markers in 92 MSI-high CRC patien...

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Bibliographic Details
Main Authors: Shih-Ching Chang, Anna Fen-Yau Li, Pei-Ching Lin, Chun-Chi Lin, Hung-Hsin Lin, Shen-Chieh Huang, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Jen-Kou Lin, Shung-Haur Yang, Yuan-Tzu Lan
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
colorectal cancer
microsatellite instability
mutation
CpG island methylator phenotype
Online Access:https://www.mdpi.com/2072-6694/12/11/3487

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