Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats
Despite the fact that zinc is recognized to be less hazardous than other heavy metals, e.g. cadmium, lead, mercury and arsenic, it may cause acute and chronic toxicities in case of exposure to high doses. Aims of the study : To investigate biochemical and histopathological toxic effects of zinc acet...
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| Format: | Article |
| Language: | English |
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Egyptian Society for Animal Management
2023-10-01
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| Series: | Journal of Applied Veterinary Sciences |
| Subjects: | |
| Online Access: | https://javs.journals.ekb.eg/article_314746_55e92304690437200f50ce5076d297bc.pdf |
| _version_ | 1827798591765217280 |
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| author | Mahmood Ali Maha AL-Saffar AL-Saffar Karam AL-mallah |
| author_facet | Mahmood Ali Maha AL-Saffar AL-Saffar Karam AL-mallah |
| author_sort | Mahmood Ali |
| collection | DOAJ |
| description | Despite the fact that zinc is recognized to be less hazardous than other heavy metals, e.g. cadmium, lead, mercury and arsenic, it may cause acute and chronic toxicities in case of exposure to high doses. Aims of the study : To investigate biochemical and histopathological toxic effects of zinc acetate on rats kidney. Material and Methods: Twenty five healthy male albino rats were divided into five equal groups : Normal saline solution was given to the control group, groups 2,3,4, and 5 received zinc acetate (4,8,12, and 24mg/kg) respectively, all the treatment were given intraperitoneally once every other day for 3 consecutive weeks, for serum biochemical evaluation and renal histopathological assessment. Results : There was a significant increment in serum urea concentration in group 5 in comparison with other groups, but there was no significant difference in creatinine concentration between all of the groups (P ≤ 0.01), histopathological examination of kidney sections of rats of different groups revealed different lesions which were more severe at 4th and 5th groups. In conclusion: Subacute zinc acetate toxicity produce a dose-dependent significant effects on serum urea concentration in all the treated groups without any significant effects on creatinine concentration, this effect was reflected on renal histo-architecture which was more severe at 4th and 5th groups. |
| first_indexed | 2024-03-11T19:39:07Z |
| format | Article |
| id | doaj.art-f5045338c540419d9eaa3347f6cc1463 |
| institution | Directory Open Access Journal |
| issn | 1687-4072 2090-3308 |
| language | English |
| last_indexed | 2024-03-11T19:39:07Z |
| publishDate | 2023-10-01 |
| publisher | Egyptian Society for Animal Management |
| record_format | Article |
| series | Journal of Applied Veterinary Sciences |
| spelling | doaj.art-f5045338c540419d9eaa3347f6cc14632023-10-06T13:06:16ZengEgyptian Society for Animal ManagementJournal of Applied Veterinary Sciences1687-40722090-33082023-10-0184374210.21608/javs.2023.218887.1248314746Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino RatsMahmood Ali0Maha AL-Saffar AL-Saffar1Karam AL-mallah2Ministry of Health, Nineveh Health Directorate, Mosul, IraqDepartment of Dental Basic Sciences, College of Dentistry. University of Mosul, Mosul, IraqPathology and poultry diseases Department , College of Veterinary Medicine. University of Mosul, IraqDespite the fact that zinc is recognized to be less hazardous than other heavy metals, e.g. cadmium, lead, mercury and arsenic, it may cause acute and chronic toxicities in case of exposure to high doses. Aims of the study : To investigate biochemical and histopathological toxic effects of zinc acetate on rats kidney. Material and Methods: Twenty five healthy male albino rats were divided into five equal groups : Normal saline solution was given to the control group, groups 2,3,4, and 5 received zinc acetate (4,8,12, and 24mg/kg) respectively, all the treatment were given intraperitoneally once every other day for 3 consecutive weeks, for serum biochemical evaluation and renal histopathological assessment. Results : There was a significant increment in serum urea concentration in group 5 in comparison with other groups, but there was no significant difference in creatinine concentration between all of the groups (P ≤ 0.01), histopathological examination of kidney sections of rats of different groups revealed different lesions which were more severe at 4th and 5th groups. In conclusion: Subacute zinc acetate toxicity produce a dose-dependent significant effects on serum urea concentration in all the treated groups without any significant effects on creatinine concentration, this effect was reflected on renal histo-architecture which was more severe at 4th and 5th groups.https://javs.journals.ekb.eg/article_314746_55e92304690437200f50ce5076d297bc.pdfzinc nephrotoxicityureacreatininepathological changes |
| spellingShingle | Mahmood Ali Maha AL-Saffar AL-Saffar Karam AL-mallah Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats Journal of Applied Veterinary Sciences zinc nephrotoxicity urea creatinine pathological changes |
| title | Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats |
| title_full | Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats |
| title_fullStr | Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats |
| title_full_unstemmed | Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats |
| title_short | Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats |
| title_sort | biochemical and histopathological assessment of zinc acetate induced nephrotoxicity in male albino rats |
| topic | zinc nephrotoxicity urea creatinine pathological changes |
| url | https://javs.journals.ekb.eg/article_314746_55e92304690437200f50ce5076d297bc.pdf |
| work_keys_str_mv | AT mahmoodali biochemicalandhistopathologicalassessmentofzincacetateinducednephrotoxicityinmalealbinorats AT mahaalsaffaralsaffar biochemicalandhistopathologicalassessmentofzincacetateinducednephrotoxicityinmalealbinorats AT karamalmallah biochemicalandhistopathologicalassessmentofzincacetateinducednephrotoxicityinmalealbinorats |