Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia

Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia

Perinatal hypoxia-ischemia (HI) is still a significant contributor to mortality and adverse neurodevelopmental outcomes in term and preterm infants. HI brain injury evolves over hours to days, and involves complex interactions between the endogenous protective and pathological processes. Understandi...

Full description

Bibliographic Details
Main Authors:	Simerdeep K. Dhillon, Eleanor R. Gunn, Benjamin A. Lear, Victoria J. King, Christopher A. Lear, Guido Wassink, Joanne O. Davidson, Laura Bennet, Alistair J. Gunn
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Pediatrics
Subjects:	cerebral blood flow hypoxia-ischemia brain biomarkers fetal sheep neonatal encephalopathy monitoring
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2022.925951/full

Similar Items

Deep Learning for Generalized EEG Seizure Detection after Hypoxia–Ischemia—Preclinical Validation
by: Hamid Abbasi, et al.
Published: (2024-02-01)

Lack of Neuroprotection with a Single Intravenous Infusion of Human Amnion Epithelial Cells after Severe Hypoxia–Ischemia in Near-Term Fetal Sheep
by: Joanne O. Davidson, et al.
Published: (2022-07-01)

The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep
by: Simerdeep K. Dhillon, et al.
Published: (2020-04-01)

Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?
by: Anthony Davies, et al.
Published: (2019-01-01)

Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy - where to from here?
by: Joanne O. Davidson, et al.
Published: (2015-09-01)

Early Signatures of Brain Injury in the Preterm Neonatal EEG
by: Hamid Abbasi, et al.
Published: (2023-09-01)

Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep
by: Kenta H.T. Cho, et al.
Published: (2021-06-01)

Effects of Three Different Doses of Inter-Alpha Inhibitor Proteins on Severe Hypoxia–Ischemia-Related Brain Injury in Neonatal Rats
by: Liam M. Koehn, et al.
Published: (2022-11-01)

Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain
by: Clémence Disdier, et al.
Published: (2020-05-01)

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges
by: Lancelot J. Millar, et al.
Published: (2017-05-01)

Challenges in developing therapeutic strategies for mild neonatal encephalopathy
by: Alice McDouall, et al.
Published: (2022-01-01)

Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep
by: Panzao Yang, et al.
Published: (2020-09-01)

TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$ ER α -dependent in adult mice following neonatal hypoxia ischemia
by: Vishal Chanana, et al.
Published: (2024-01-01)

Glia and hemichannels: key mediators of perinatal encephalopathy
by: Robert Galinsky, et al.
Published: (2018-01-01)

Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses
by: Victoria J. King, et al.
Published: (2022-08-01)

Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep
by: Kelly Q. Zhou, et al.
Published: (2022-06-01)

Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia
by: Hélène Roumes, et al.
Published: (2022-09-01)

Changes in Cellular Localization of Inter-Alpha Inhibitor Proteins after Cerebral Ischemia in the Near-Term Ovine Fetus
by: Kazuki Hatayama, et al.
Published: (2021-10-01)

Targeting Persistent Neuroinflammation after Hypoxic-Ischemic Encephalopathy—Is Exendin-4 the Answer?
by: Kelly Q. Zhou, et al.
Published: (2022-09-01)

Use of ultraselective derivate of clonidine for prolonged sedation in term newborns with hypoxic-ischemic encephalopathy
by: D.M. Surkov
Published: (2019-12-01)

Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia–Ischemia With and Without Inflammation-Sensitization
by: Raymand Pang, et al.
Published: (2020-09-01)

THE ROLE OF NEUROGLOBIN IN CEREBRAL ISCHEMIA / HYPOXIA AND OTHER NEUROPATHOLOGY
by: Zimatkin S. M., et al.
Published: (2018-12-01)

The mechanisms and treatment of asphyxial encephalopathy
by: Guido eWassink, et al.
Published: (2014-02-01)

Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia
by: Jessica M. Livingston, et al.
Published: (2020-08-01)

Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic review
by: Panagiotis Christidis, et al.
Published: (2022-11-01)

Perinatal Brain Injury and Inflammation: Lessons from Experimental Murine Models
by: Aisling Leavy, et al.
Published: (2020-12-01)

The assessment of general movements in term and late-preterm infants diagnosed with neonatal encephalopathy, as a predictive tool of cerebral palsy by 2 years of age—a scoping review
by: Judy Seesahai, et al.
Published: (2021-08-01)

Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain
by: Nicolas Dupré, et al.
Published: (2020-12-01)

Impact of Hypoxia-Ischemia on Neurogenesis and Structural and Functional Outcomes in a Mild–Moderate Neonatal Hypoxia-Ischemia Brain Injury Model
by: Anne Ehlting, et al.
Published: (2022-07-01)

Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep
by: Panzao Yang, et al.
Published: (2023-02-01)

Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia–ischemia in the newborn rat
by: Silvia Carloni, et al.
Published: (2006-01-01)

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research
by: Dianne G. Kleuskens, et al.
Published: (2021-02-01)

Effect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice
by: Bérénice Le Dieu-Lugon, et al.
Published: (2021-04-01)

URB447 Is Neuroprotective in Both Male and Female Rats after Neonatal Hypoxia–Ischemia and Enhances Neurogenesis in Females
by: Gorane Beldarrain, et al.
Published: (2024-01-01)

Neuroprotective Effect of Maternal Resveratrol Supplementation in a Rat Model of Neonatal Hypoxia-Ischemia
by: Ursule Dumont, et al.
Published: (2021-01-01)

The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia
by: Sean Quinlan, et al.
Published: (2019-07-01)

Neurogenesis Is Reduced at 48 h in the Subventricular Zone Independent of Cell Death in a Piglet Model of Perinatal Hypoxia-Ischemia
by: Daniel Alonso-Alconada, et al.
Published: (2022-04-01)

Induction of Mitochondrial Fragmentation and Mitophagy after Neonatal Hypoxia–Ischemia
by: Syam Nair, et al.
Published: (2022-04-01)

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia
by: Kevin D. Broad, et al.
Published: (2016-03-01)

A comparison between chemical and gas hypoxia as models of global ischemia in zebrafish (Danio rerio)
by: Kaitlyn M. Marino, et al.
Published: (2020-09-01)