PPAR-Gamma Activation May Inhibit the In Vivo Degeneration of Bioprosthetic Aortic and Aortic Valve Grafts under Diabetic Conditions

PPAR-Gamma Activation May Inhibit the In Vivo Degeneration of Bioprosthetic Aortic and Aortic Valve Grafts under Diabetic Conditions

Background: We aimed to examine the anti-calcification and anti-inflammatory effects of pioglitazone as a PPAR-gamma agonist on bioprosthetic-valve-bearing aortic grafts in a rat model of diabetes mellitus (DM). Methods: DM was induced in male Wistar rats by high-fat diet with an intraperitoneal str...

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Bibliographic Details
Main Authors: Shintaro Katahira, Yukiharu Sugimura, Sophia Grupp, Robin Doepp, Jessica Isabel Selig, Mareike Barth, Artur Lichtenberg, Payam Akhyari
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes mellitus
allograft
bioprosthetic valve
degeneration
PPAR-gamma
pioglitazone
Online Access:https://www.mdpi.com/1422-0067/22/20/11081

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