An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae
Small regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria. Here, the authors identify Hfq-interacting sRNAs and their targets in the pathogen Vibrio cholerae, including an RNA sponge that binds and inactivates...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35261-x |
| _version_ | 1811302158614659072 |
|---|---|
| author | Michaela Huber Anne Lippegaus Sahar Melamed Malte Siemers Benjamin R. Wucher Mona Hoyos Carey Nadell Gisela Storz Kai Papenfort |
| author_facet | Michaela Huber Anne Lippegaus Sahar Melamed Malte Siemers Benjamin R. Wucher Mona Hoyos Carey Nadell Gisela Storz Kai Papenfort |
| author_sort | Michaela Huber |
| collection | DOAJ |
| description | Small regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria. Here, the authors identify Hfq-interacting sRNAs and their targets in the pathogen Vibrio cholerae, including an RNA sponge that binds and inactivates four sRNAs that modulate the quorum sensing pathway. |
| first_indexed | 2024-04-13T07:23:02Z |
| format | Article |
| id | doaj.art-f507f04b470841c69f90b04b2bd9656c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T07:23:02Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f507f04b470841c69f90b04b2bd9656c2022-12-22T02:56:33ZengNature PortfolioNature Communications2041-17232022-12-0113111410.1038/s41467-022-35261-xAn RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio choleraeMichaela Huber0Anne Lippegaus1Sahar Melamed2Malte Siemers3Benjamin R. Wucher4Mona Hoyos5Carey Nadell6Gisela Storz7Kai Papenfort8Friedrich Schiller University Jena, Institute of MicrobiologyFriedrich Schiller University Jena, Institute of MicrobiologyDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentFriedrich Schiller University Jena, Institute of MicrobiologyDepartment of Biological Sciences, Dartmouth CollegeFriedrich Schiller University Jena, Institute of MicrobiologyDepartment of Biological Sciences, Dartmouth CollegeDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentFriedrich Schiller University Jena, Institute of MicrobiologySmall regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria. Here, the authors identify Hfq-interacting sRNAs and their targets in the pathogen Vibrio cholerae, including an RNA sponge that binds and inactivates four sRNAs that modulate the quorum sensing pathway.https://doi.org/10.1038/s41467-022-35261-x |
| spellingShingle | Michaela Huber Anne Lippegaus Sahar Melamed Malte Siemers Benjamin R. Wucher Mona Hoyos Carey Nadell Gisela Storz Kai Papenfort An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae Nature Communications |
| title | An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae |
| title_full | An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae |
| title_fullStr | An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae |
| title_full_unstemmed | An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae |
| title_short | An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae |
| title_sort | rna sponge controls quorum sensing dynamics and biofilm formation in vibrio cholerae |
| url | https://doi.org/10.1038/s41467-022-35261-x |
| work_keys_str_mv | AT michaelahuber anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT annelippegaus anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT saharmelamed anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT maltesiemers anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT benjaminrwucher anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT monahoyos anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT careynadell anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT giselastorz anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT kaipapenfort anrnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT michaelahuber rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT annelippegaus rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT saharmelamed rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT maltesiemers rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT benjaminrwucher rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT monahoyos rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT careynadell rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT giselastorz rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae AT kaipapenfort rnaspongecontrolsquorumsensingdynamicsandbiofilmformationinvibriocholerae |