Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy

Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy

Background: Cladribine (2-CdA) can cross the blood–brain barrier, resulting in inhibition of DNA synthesis and repair and disruption of cellular proliferation in actively dividing lymphocytes. No data on effect on neurons are available. Aim: To study “in vitro” 2-CdA apoptotic effects on neurons in...

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Bibliographic Details
Main Authors: Maddalena Ruggieri, Concetta Domenica Gargano, Anna Ferretta, Alessia Manni, Antonio Capacchione, Antonio Frigeri, Pietro Iaffaldano, Maria Trojano, Damiano Paolicelli
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Brain Sciences
Subjects:
multiple sclerosis
cladribine
apoptosis
neurons
Online Access:https://www.mdpi.com/2076-3425/10/8/548

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